%0 Case Reports
%T Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report.
%A Jung R
%A Ly K
%A Taniguchi M
%A Arriola AG
%A Gravante C
%A Shinn D
%A Mathew L
%A Hamad E
%A Geier S
%A Liacini A
%J Int J Mol Sci
%V 25
%N 4
%D 2024 Feb 12
%M 38396895
%F 6.208
%R 10.3390/ijms25042218
%X HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.