{Reference Type}: Case Reports
{Title}: Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report.
{Author}: Jung R;Ly K;Taniguchi M;Arriola AG;Gravante C;Shinn D;Mathew L;Hamad E;Geier S;Liacini A;
{Journal}: Int J Mol Sci
{Volume}: 25
{Issue}: 4
{Year}: 2024 Feb 12
{Factor}: 6.208
{DOI}: 10.3390/ijms25042218
{Abstract}: HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.