PDF(Pubmed)
Abstract：
Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between the vascular system and degenerative diseases, shedding light on the underlying mechanisms and profound implications for disease progression and management. The pivotal role of the vascular system in maintaining tissue homeostasis is highlighted, as it serves as the conduit for oxygen, nutrients, and immune cells to vital organs and tissues. Due to the vital role of the vascular system in maintaining homeostasis, its dysfunction, characterized by impaired blood flow, endothelial dysfunction, and vascular inflammation, emerges as a common denominator of degenerative diseases across multiple systems. In the nervous system, we explored the influence of vascular factors on neurodegenerative diseases such as Alzheimer\'s and Parkinson\'s, emphasizing the critical role of cerebral blood flow regulation and the blood-brain barrier. Within the kidney system, the intricate relationship between vascular health and chronic kidney disease is scrutinized, unraveling the mechanisms by which hypertension and other vascular factors contribute to renal dysfunction. Throughout this review, we emphasize the clinical significance of understanding vascular involvement in degenerative diseases and potential therapeutic interventions targeting vascular health, highlighting emerging treatments and prevention strategies. In conclusion, a profound appreciation of the role of the vascular system in degenerative diseases is essential for advancing our understanding of degenerative disease pathogenesis and developing innovative approaches for prevention and treatment. This review provides a comprehensive foundation for researchers, clinicians, and policymakers seeking to address the intricate relationship between vascular health and degenerative diseases in pursuit of improved patient outcomes and enhanced public health.
摘要：
退行性疾病,包括影响各种器官系统的各种条件，对全球医疗保健系统构成重大挑战。这篇全面的综述探讨了血管系统与退行性疾病之间的复杂相互作用，阐明疾病进展和管理的潜在机制和深远影响。强调了血管系统在维持组织稳态方面的关键作用，因为它是氧气的管道，营养素,和免疫细胞到重要的器官和组织。由于血管系统在维持体内平衡方面的重要作用，它的功能障碍，以血流受损为特征，内皮功能障碍,血管炎症，作为跨多个系统的退行性疾病的共同点而出现。在神经系统中，我们探讨了血管因素对神经退行性疾病如阿尔茨海默病和帕金森病的影响,强调脑血流调节和血脑屏障的关键作用。在肾脏系统中，血管健康和慢性肾脏病之间错综复杂的关系被仔细研究,揭示高血压和其他血管因素导致肾功能障碍的机制。在整个审查过程中，我们强调了解血管参与退行性疾病和针对血管健康的潜在治疗干预的临床意义，强调新兴的治疗和预防策略。总之,对血管系统在退行性疾病中的作用的深刻理解对于提高我们对退行性疾病发病机制的理解以及开发预防和治疗的创新方法至关重要。这篇综述为研究人员提供了全面的基础，临床医生,和政策制定者寻求解决血管健康和退行性疾病之间的复杂关系，以寻求改善患者预后和增强公共卫生。
