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Abstract：
OBJECTIVE: In older adults with Alzheimer\'s disease, slowing of electroencephalographic (EEG) activity during REM sleep has been observed. Few studies have examined EEG slowing during REM in those with mild cognitive impairment (MCI) and none have examined its relationship with cognition in this at-risk population.
METHODS: Two hundred and ten older adults (mean age = 67.0, SD = 8.2 years) underwent comprehensive neuropsychological, medical, and psychiatric assessment and overnight polysomnography. Participants were classified as subjective cognitive impairment (SCI; n = 75), non-amnestic MCI (naMCI, n = 85), and amnestic MCI (aMCI, n = 50). REM EEG slowing was defined as (δ + θ)/(α + σ + β) power and calculated for frontal, central, parietal, and occipital regions. Analysis of variance compared REM EEG slowing between groups. Correlations between REM EEG slowing and cognition, including learning and memory, visuospatial and executive functions, were examined within each subgroup.
RESULTS: The aMCI group had significantly greater REM EEG slowing in the parietal and occipital regions compared to the naMCI and SCI groups (partial η2 = 0.06, p < 0.05 and 0.06, p < 0.05, respectively), and greater EEG slowing in the central region compared to SCI group (partial η2 = 0.03, p < 0.05). Greater REM EEG slowing in parietal (r = -0.49) and occipital regions (r = -0.38 [O1/M2] and -0.33 [O2/M1]) were associated with poorer visuospatial performance in naMCI.
CONCLUSIONS: REM EEG slowing may differentiate older adults with memory impairment from those without. Longitudinal studies are now warranted to examine the prognostic utility of REM EEG slowing for cognitive and dementia trajectories.
METHODS: Two hundred and ten older adults (mean age = 67.0, SD = 8.2 years) underwent comprehensive neuropsychological, medical, and psychiatric assessment and overnight polysomnography. Participants were classified as subjective cognitive impairment (SCI; n = 75), non-amnestic MCI (naMCI, n = 85), and amnestic MCI (aMCI, n = 50). REM EEG slowing was defined as (δ + θ)/(α + σ + β) power and calculated for frontal, central, parietal, and occipital regions. Analysis of variance compared REM EEG slowing between groups. Correlations between REM EEG slowing and cognition, including learning and memory, visuospatial and executive functions, were examined within each subgroup.
RESULTS: The aMCI group had significantly greater REM EEG slowing in the parietal and occipital regions compared to the naMCI and SCI groups (partial η2 = 0.06, p < 0.05 and 0.06, p < 0.05, respectively), and greater EEG slowing in the central region compared to SCI group (partial η2 = 0.03, p < 0.05). Greater REM EEG slowing in parietal (r = -0.49) and occipital regions (r = -0.38 [O1/M2] and -0.33 [O2/M1]) were associated with poorer visuospatial performance in naMCI.
CONCLUSIONS: REM EEG slowing may differentiate older adults with memory impairment from those without. Longitudinal studies are now warranted to examine the prognostic utility of REM EEG slowing for cognitive and dementia trajectories.
摘要：
目标：在患有阿尔茨海默病的老年人中，已观察到REM睡眠期间脑电图（EEG）活动减慢。很少有研究研究了轻度认知障碍（MCI）患者在REM过程中的EEG减慢，也没有研究该高危人群与认知的关系。
方法：210名老年人（平均年龄=67.0，sd=8.2岁）接受了全面的神经心理学，medical,以及精神病评估和夜间多导睡眠图。参与者被归类为主观认知障碍(SCI；n=75)，非遗忘型MCI（naMCI，n=85），和遗忘型MCI（aMCI，n=50）。REMEEG减慢被定义为(delta+theta)/(alpha+sigma+beta)功率和额叶计算,中央,顶叶,和枕骨区域。比拟各组间REM脑电图减缓的方差剖析。REM脑电图减慢与认知的相关性，包括学习和记忆，视觉空间和执行功能，在每个亚组内进行检查。
结果：与naMCI和SCI组相比，aMCI组的顶叶和枕骨区域的REMEEG减慢明显更大（部分η2=0.06，p<0.05和0.06，p<0.05），与SCI组相比，中央区域的EEG减慢更大（部分η2=0.03，p<0.05）。顶叶（r=-0.49）和枕骨区域（r=-0.38（O1/M2）和-0.33（O2/M1）的REMEEG减慢与naMCI的视觉空间表现较差相关。
结论：REMEEG减慢可以区分有记忆障碍的老年人和无记忆障碍的老年人。现在有必要进行纵向研究，以检查REMEEG减慢认知和痴呆轨迹的预后效用。
方法：210名老年人（平均年龄=67.0，sd=8.2岁）接受了全面的神经心理学，medical,以及精神病评估和夜间多导睡眠图。参与者被归类为主观认知障碍(SCI；n=75)，非遗忘型MCI（naMCI，n=85），和遗忘型MCI（aMCI，n=50）。REMEEG减慢被定义为(delta+theta)/(alpha+sigma+beta)功率和额叶计算,中央,顶叶,和枕骨区域。比拟各组间REM脑电图减缓的方差剖析。REM脑电图减慢与认知的相关性，包括学习和记忆，视觉空间和执行功能，在每个亚组内进行检查。
结果：与naMCI和SCI组相比，aMCI组的顶叶和枕骨区域的REMEEG减慢明显更大（部分η2=0.06，p<0.05和0.06，p<0.05），与SCI组相比，中央区域的EEG减慢更大（部分η2=0.03，p<0.05）。顶叶（r=-0.49）和枕骨区域（r=-0.38（O1/M2）和-0.33（O2/M1）的REMEEG减慢与naMCI的视觉空间表现较差相关。
结论：REMEEG减慢可以区分有记忆障碍的老年人和无记忆障碍的老年人。现在有必要进行纵向研究，以检查REMEEG减慢认知和痴呆轨迹的预后效用。
