Abstract:
The study subject was a healthy, 47-year-old man, a low temperature Guinness World Record holder. He spent 50 days alone in Rovaniemi, Lapland, and functioned in the ambient temperature ranging from +2°C to -37°C. He did not use sources of heat, he did not eat warm meals or drink hot water, and did not dry his clothes. He slept in an igloo, on an ice cover of 20-30 cm. He spent 10 hours a day in a sleeping bag and for the remaining time he walked, skied, or rode a bicycle, and practiced swimming. The aim of the study was a laboratory assessment of renal capacity in a man exposed to long-term extremely low ambient temperatures. The study was approved by the Ethical Committee at the Regional Medical Chamber in Krakow, Poland (approval No.: 194/KBL/OIL/2019). Twice during the observation, urine and blood were collected and analyzed: before and after the prolonged exposure to extremely low ambient temperatures. Changes were seen in many blood and urine parameters, but in urine, they were more significant. In urine, decreased values of sodium (by 53.9%), potassium (by 22.6%), creatinine (by 65.5%), urea (by 61.3%), uric acid (by 58.4%), and protein (by 50%) were observed. Neutrophil gelatinase-associated lipocalin (NGAL) increased by 34%. Absence of calcium oxalate excretion was reported relative to the value before the exposure to cold. In blood, increased values of interleukin-6 (by 60%) and β-2-microglobulin (by 26.9%) were observed. Erythropoietin decreased by 22.4%. No changes were noted in estimated glomerular filtration rate. The study subject lost 10 kg in weight. On the basis of the results obtained during the observation, it can be determined that the probable cause of changes in the laboratory results of the subject was the diet used, and not a dysfunction of the excretory system. The body weight loss and activation of compensating mechanisms focused on saving vitally important diet components, caused by the insufficient diet, exclude the theory of a negative effect of exposure to extremely low temperatures on renal filtration function.
摘要:
研究对象是一个健康的,47岁的男人,低温吉尼斯世界纪录保持者.他独自在罗瓦涅米呆了50天,拉普兰,并在+2°C至-37°C的环境温度下起作用。他没有使用热源,他不吃热食或喝热水,也没有擦干他的衣服。他睡在冰屋,在20-30厘米的冰盖上。他每天在睡袋里呆10个小时,剩下的时间他走路,skied,或者骑自行车,练习游泳。该研究的目的是对长期暴露于极低环境温度的男性的肾脏能力进行实验室评估。这项研究得到了克拉科夫地区医疗分庭伦理委员会的批准,波兰(批准号:194/KBL/石油/2019)。在观察期间两次,在长时间暴露于极低环境温度之前和之后,收集并分析尿液和血液。许多血液和尿液参数都有变化,但在尿液中,他们更重要。在尿液中,钠值下降(53.9%),钾(22.6%),肌酐(65.5%),尿素(61.3%),尿酸(下降58.4%),观察到蛋白质(50%)。中性粒细胞明胶酶相关脂质运载蛋白(NGAL)增加了34%。相对于暴露于寒冷之前的值,报告了草酸钙排泄的缺乏。在血液中,观察到白细胞介素-6(60%)和β-2-微球蛋白(26.9%)的值增加。促红细胞生成素下降22.4%。估计的肾小球滤过率没有变化。研究对象体重减轻了10kg。根据观察过程中获得的结果,可以确定受试者实验室结果变化的可能原因是所使用的饮食,而不是排泄系统的功能障碍。身体体重减轻和补偿机制的激活集中于保存至关重要的饮食成分,由于饮食不足,排除暴露于极低温度对肾脏过滤功能的负面影响的理论。