PDF(Pubmed)
Abstract：
Entomophthoromycosis constitutes a nosological group of subcutaneous mycoses including conidiobolomycosis (rhinofacial form) and basidiobomomycosis (subcutaneous form involving the trunk and the limbs). Conidiobolomycosis is characterized by a progressive nasal and facial deformity giving, in the evolved forms, a \"hippopotamus snout\". The literature review finds a hundred cases, with a tropism for the humid tropical regions. Methods. We report the observation of a 25-year-old patient, living in the equatorial zone, in the south of Gabon in a humid forest area, presenting a swollen aspect of the face mainly involving the eyelids, the nose and the upper lips.
The diagnosis of entomophthoromycosis was compatible with the histopathological and clinical aspects. The evolution was favorable in terms of facial aesthetics under itraconazole 300 mg/day for 2 months and corticosteroid therapy (bolus of methylprednisone 240 mg/day for 3 days relayed per os at a dose of 0.5 mg/kg/day, i.e. 30 mg/day) of prednisone), maintained for 3 months. The average nasal improvement could not be completed by surgery and the patient was lost to follow-up.
This second observation of conidiobolomycosis in Gabon in the same province makes Ngounié a privileged ecosystem for this affection.
The diagnosis of entomophthoromycosis was compatible with the histopathological and clinical aspects. The evolution was favorable in terms of facial aesthetics under itraconazole 300 mg/day for 2 months and corticosteroid therapy (bolus of methylprednisone 240 mg/day for 3 days relayed per os at a dose of 0.5 mg/kg/day, i.e. 30 mg/day) of prednisone), maintained for 3 months. The average nasal improvement could not be completed by surgery and the patient was lost to follow-up.
This second observation of conidiobolomycosis in Gabon in the same province makes Ngounié a privileged ecosystem for this affection.
摘要：
■肠真菌病构成了一组皮下真菌病，包括分生孢子菌病（鼻面形式）和基底细菌菌病（涉及躯干和四肢的皮下形式）。分生孢子菌病的特点是进行性鼻和面部畸形，在进化的形式中，“河马鼻子”。文献回顾发现了一百个案例，对潮湿的热带地区有吸引力。方法。我们报道了一名25岁患者的观察结果，生活在赤道地带,在加蓬南部潮湿的森林地区，面部肿胀，主要累及眼睑，鼻子和上唇。
■虫卵真菌病的诊断与组织病理学和临床方面一致。在伊曲康唑300mg/天持续2个月和皮质类固醇治疗下，面部美学方面的发展是有利的（甲基强的松240mg/天持续3天，以0.5mg/kg/天的剂量口服，即30毫克/天)泼尼松)，维持3个月。手术无法完成平均鼻部改善，患者失去了随访。
■在同一省的加蓬对分生孢子病的第二次观察使Ngounié成为这种情感的特权生态系统。
■虫卵真菌病的诊断与组织病理学和临床方面一致。在伊曲康唑300mg/天持续2个月和皮质类固醇治疗下，面部美学方面的发展是有利的（甲基强的松240mg/天持续3天，以0.5mg/kg/天的剂量口服，即30毫克/天)泼尼松)，维持3个月。手术无法完成平均鼻部改善，患者失去了随访。
■在同一省的加蓬对分生孢子病的第二次观察使Ngounié成为这种情感的特权生态系统。
