Abstract：
OBJECTIVE: To investigate the impact of disease duration on clinical phenotypes in Chinese patients with primary Sjögren syndrome (pSS) and examine the correlation between clinical phenotypes and onset age, age at diagnosis, and disease duration.
METHODS: Data from 952 patients diagnosed with pSS in China between January 2013 and March 2022 were analyzed based on medical records. Patients were categorized into 3 groups based on disease duration: short (<5 years), moderate (≥5 and <10 years), and long (≥10 years) group. Clinical characteristics were compared among the 3 groups, and pSS patients with a long disease duration were compared with the other patients after matching age at diagnosis and age at onset.
RESULTS: Among the patients, 20.4% had a disease duration over 10 years. After matching for age at onset and age at diagnosis, pSS patients with a long disease duration exhibited a significantly higher prevalence of dry mouth ( p <0.001), dry eyes ( p <0.001), fatigue ( p <0.001), arthralgia ( p <0.001), and dental caries ( p <0.001) and higher rates of anti-Sjögren syndrome A ( p < 0.05), anti-Ro52 ( p < 0.05), and anti-SSB ( p < 0.05) positivity than their control groups, with prevalence increasing with disease duration ( ptrend < 0.001). However, no differences were noted in the prevalence of interstitial lung disease and leukopenia between different disease duration groups after matching for age at onset, although differences were shown when matching for age at diagnosis.
CONCLUSIONS: Longer disease duration in pSS patients correlates with increased prevalence of sicca symptoms, fatigue, and arthralgia and higher positivity of autoantibodies associated with pSS. However, the prevalence of interstitial lung disease and leukopenia did not correlate with disease duration after matching for age at onset.
METHODS: Data from 952 patients diagnosed with pSS in China between January 2013 and March 2022 were analyzed based on medical records. Patients were categorized into 3 groups based on disease duration: short (<5 years), moderate (≥5 and <10 years), and long (≥10 years) group. Clinical characteristics were compared among the 3 groups, and pSS patients with a long disease duration were compared with the other patients after matching age at diagnosis and age at onset.
RESULTS: Among the patients, 20.4% had a disease duration over 10 years. After matching for age at onset and age at diagnosis, pSS patients with a long disease duration exhibited a significantly higher prevalence of dry mouth ( p <0.001), dry eyes ( p <0.001), fatigue ( p <0.001), arthralgia ( p <0.001), and dental caries ( p <0.001) and higher rates of anti-Sjögren syndrome A ( p < 0.05), anti-Ro52 ( p < 0.05), and anti-SSB ( p < 0.05) positivity than their control groups, with prevalence increasing with disease duration ( ptrend < 0.001). However, no differences were noted in the prevalence of interstitial lung disease and leukopenia between different disease duration groups after matching for age at onset, although differences were shown when matching for age at diagnosis.
CONCLUSIONS: Longer disease duration in pSS patients correlates with increased prevalence of sicca symptoms, fatigue, and arthralgia and higher positivity of autoantibodies associated with pSS. However, the prevalence of interstitial lung disease and leukopenia did not correlate with disease duration after matching for age at onset.
摘要：
目的：探讨病程对中国原发性干燥综合征（pSS）患者临床表型的影响，并探讨临床表型与发病年龄的相关性。诊断时的年龄，和疾病持续时间。
方法：对2013年1月至2022年3月在中国诊断为pSS的952例患者的数据进行分析。根据疾病持续时间将患者分为3组：短（<5年），中度（≥5年和<10年），和长期（≥10年）组。比较3组临床特点,在诊断年龄和发病年龄匹配后，将病程较长的pSS患者与其他患者进行比较。
结果：在患者中，20.4％的疾病持续时间超过10年。在匹配发病年龄和诊断年龄后，病程较长的pSS患者的口干患病率明显较高（p<0.001），干眼症（p<0.001），疲劳(p<0.001)，关节痛（p<0.001），和龋齿（p<0.001）和更高的抗干燥综合征A（p<0.05），抗Ro52（p<0.05），和抗SSB(p<0.05)阳性高于对照组，患病率随病程的增加而增加（ptrend<0.001）。然而,在发病年龄匹配后，不同疾病持续时间组之间的间质性肺病和白细胞减少的患病率没有差异。尽管在诊断时匹配年龄时显示出差异。
结论：pSS患者病程延长与干燥症状患病率增加相关，疲劳,关节痛和与pSS相关的自身抗体阳性较高。然而,根据发病年龄进行匹配后,间质性肺病和白细胞减少症的患病率与疾病持续时间无关.
方法：对2013年1月至2022年3月在中国诊断为pSS的952例患者的数据进行分析。根据疾病持续时间将患者分为3组：短（<5年），中度（≥5年和<10年），和长期（≥10年）组。比较3组临床特点,在诊断年龄和发病年龄匹配后，将病程较长的pSS患者与其他患者进行比较。
结果：在患者中，20.4％的疾病持续时间超过10年。在匹配发病年龄和诊断年龄后，病程较长的pSS患者的口干患病率明显较高（p<0.001），干眼症（p<0.001），疲劳(p<0.001)，关节痛（p<0.001），和龋齿（p<0.001）和更高的抗干燥综合征A（p<0.05），抗Ro52（p<0.05），和抗SSB(p<0.05)阳性高于对照组，患病率随病程的增加而增加（ptrend<0.001）。然而,在发病年龄匹配后，不同疾病持续时间组之间的间质性肺病和白细胞减少的患病率没有差异。尽管在诊断时匹配年龄时显示出差异。
结论：pSS患者病程延长与干燥症状患病率增加相关，疲劳,关节痛和与pSS相关的自身抗体阳性较高。然而,根据发病年龄进行匹配后,间质性肺病和白细胞减少症的患病率与疾病持续时间无关.
