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Abstract：
UNASSIGNED: To explore the association between the number of missing teeth and the prevalence of hyperlipidemia in a Chinese adult population.
UNASSIGNED: 13,932 adults were investigated in the TCLSIH cohort study. The number of missing teeth was determined at baseline through a self-reported questionnaire, and then classified into three categories: 0, 1-2, and ≥3. We defined hyperlipidemia as total cholesterol (TC) ≥ 5.17 mmol/L or triglycerides (TG) ≥ 1.7 mmol/L or low-density lipoprotein (LDL) cholesterol ≥ 3.37 mmol/L or a self-report of physician-diagnosed hyperlipidemia during follow-up visits. Cox proportional-hazards regression models were employed to assess the relationship between the number of missing teeth and incident hyperlipidemia.
UNASSIGNED: A total of 6756 first-incident cases of hyperlipidemia occurred during 42,048 person-years of follow-up (median follow-up, 4.2 years). After adjusted confounders, multivariable HRs and 95% CI for incident of hyperlipidemia across the categories of missing teeth were as follows: in male participants, 1.00 (reference), 1.10 (0.98, 1.22), and 1.03 (0.91, 1.16) (P for trend = 0.30); in female participants, 1.00 (reference), 1.09 (0.99, 1.19), and 1.18 (1.04, 1.33) (P for trend < 0.01).
UNASSIGNED: The number of missing teeth is associated with an increased risk of hyperlipidemia in female participants but not in male participants. Systemic chronic inflammation may potentially mediate this association.
UNASSIGNED: 13,932 adults were investigated in the TCLSIH cohort study. The number of missing teeth was determined at baseline through a self-reported questionnaire, and then classified into three categories: 0, 1-2, and ≥3. We defined hyperlipidemia as total cholesterol (TC) ≥ 5.17 mmol/L or triglycerides (TG) ≥ 1.7 mmol/L or low-density lipoprotein (LDL) cholesterol ≥ 3.37 mmol/L or a self-report of physician-diagnosed hyperlipidemia during follow-up visits. Cox proportional-hazards regression models were employed to assess the relationship between the number of missing teeth and incident hyperlipidemia.
UNASSIGNED: A total of 6756 first-incident cases of hyperlipidemia occurred during 42,048 person-years of follow-up (median follow-up, 4.2 years). After adjusted confounders, multivariable HRs and 95% CI for incident of hyperlipidemia across the categories of missing teeth were as follows: in male participants, 1.00 (reference), 1.10 (0.98, 1.22), and 1.03 (0.91, 1.16) (P for trend = 0.30); in female participants, 1.00 (reference), 1.09 (0.99, 1.19), and 1.18 (1.04, 1.33) (P for trend < 0.01).
UNASSIGNED: The number of missing teeth is associated with an increased risk of hyperlipidemia in female participants but not in male participants. Systemic chronic inflammation may potentially mediate this association.
摘要：
■探讨中国成年人群中牙齿缺失数量与高脂血症患病率之间的关系。
■在TCLSIH队列研究中调查了13,932名成年人。通过自我报告问卷在基线时确定缺失牙齿的数量，然后分为三类：0、1-2和≥3。我们将高脂血症定义为总胆固醇（TC）≥5.17mmol/L或甘油三酸酯（TG）≥1.7mmol/L或低密度脂蛋白（LDL）胆固醇≥3.37mmol/L或医生诊断为高脂血症的自我报告随访访视。采用Cox比例风险回归模型来评估牙齿缺失数量与高脂血症之间的关系。
■在42,048人年的随访中，总共发生了6756例高脂血症的首次事件（中位随访，4.2年）。在调整了混杂因素后，在牙齿缺失的类别中，高脂血症事件的多变量HR和95%CI如下：在男性参与者中，1.00（参考），1.10(0.98,1.22),和1.03（0.91，1.16）（趋势的P=0.30）；在女性参与者中，1.00（参考），1.09(0.99,1.19),和1.18（1.04，1.33）（趋势P<0.01）。
■牙齿缺失的数量与女性参与者的高脂血症风险增加有关，而与男性参与者无关。系统性慢性炎症可能潜在地介导这种关联。
■在TCLSIH队列研究中调查了13,932名成年人。通过自我报告问卷在基线时确定缺失牙齿的数量，然后分为三类：0、1-2和≥3。我们将高脂血症定义为总胆固醇（TC）≥5.17mmol/L或甘油三酸酯（TG）≥1.7mmol/L或低密度脂蛋白（LDL）胆固醇≥3.37mmol/L或医生诊断为高脂血症的自我报告随访访视。采用Cox比例风险回归模型来评估牙齿缺失数量与高脂血症之间的关系。
■在42,048人年的随访中，总共发生了6756例高脂血症的首次事件（中位随访，4.2年）。在调整了混杂因素后，在牙齿缺失的类别中，高脂血症事件的多变量HR和95%CI如下：在男性参与者中，1.00（参考），1.10(0.98,1.22),和1.03（0.91，1.16）（趋势的P=0.30）；在女性参与者中，1.00（参考），1.09(0.99,1.19),和1.18（1.04，1.33）（趋势P<0.01）。
■牙齿缺失的数量与女性参与者的高脂血症风险增加有关，而与男性参与者无关。系统性慢性炎症可能潜在地介导这种关联。
