UNASSIGNED: 13,932 adults were investigated in the TCLSIH cohort study. The number of missing teeth was determined at baseline through a self-reported questionnaire, and then classified into three categories: 0, 1-2, and ≥3. We defined hyperlipidemia as total cholesterol (TC) ≥ 5.17 mmol/L or triglycerides (TG) ≥ 1.7 mmol/L or low-density lipoprotein (LDL) cholesterol ≥ 3.37 mmol/L or a self-report of physician-diagnosed hyperlipidemia during follow-up visits. Cox proportional-hazards regression models were employed to assess the relationship between the number of missing teeth and incident hyperlipidemia.
UNASSIGNED: A total of 6756 first-incident cases of hyperlipidemia occurred during 42,048 person-years of follow-up (median follow-up, 4.2 years). After adjusted confounders, multivariable HRs and 95% CI for incident of hyperlipidemia across the categories of missing teeth were as follows: in male participants, 1.00 (reference), 1.10 (0.98, 1.22), and 1.03 (0.91, 1.16) (P for trend = 0.30); in female participants, 1.00 (reference), 1.09 (0.99, 1.19), and 1.18 (1.04, 1.33) (P for trend < 0.01).
UNASSIGNED: The number of missing teeth is associated with an increased risk of hyperlipidemia in female participants but not in male participants. Systemic chronic inflammation may potentially mediate this association.
■在TCLSIH队列研究中调查了13,932名成年人。通过自我报告问卷在基线时确定缺失牙齿的数量,然后分为三类:0、1-2和≥3。我们将高脂血症定义为总胆固醇(TC)≥5.17mmol/L或甘油三酸酯(TG)≥1.7mmol/L或低密度脂蛋白(LDL)胆固醇≥3.37mmol/L或医生诊断为高脂血症的自我报告随访访视。采用Cox比例风险回归模型来评估牙齿缺失数量与高脂血症之间的关系。
■在42,048人年的随访中,总共发生了6756例高脂血症的首次事件(中位随访,4.2年)。在调整了混杂因素后,在牙齿缺失的类别中,高脂血症事件的多变量HR和95%CI如下:在男性参与者中,1.00(参考),1.10(0.98,1.22),和1.03(0.91,1.16)(趋势的P=0.30);在女性参与者中,1.00(参考),1.09(0.99,1.19),和1.18(1.04,1.33)(趋势P<0.01)。
■牙齿缺失的数量与女性参与者的高脂血症风险增加有关,而与男性参与者无关。系统性慢性炎症可能潜在地介导这种关联。