{Reference Type}: Journal Article
{Title}: Association Between Number of Missing Teeth and Hyperlipidemia: The TCLSIH Cohort Study.
{Author}: Qiao F;Guo H;Zhang J;Zhang Q;Liu L;Meng G;Wu H;Gu Y;Song K;Li C;Niu K;
{Journal}: J Inflamm Res
{Volume}: 17
{Issue}: 0
{Year}: 2024
{Factor}: 4.631
{DOI}: 10.2147/JIR.S443940
{Abstract}: <B>UNASSIGNED: </B>To explore the association between the number of missing teeth and the prevalence of hyperlipidemia in a Chinese adult population.<BR><B>UNASSIGNED: </B>13,932 adults were investigated in the TCLSIH cohort study. The number of missing teeth was determined at baseline through a self-reported questionnaire, and then classified into three categories: 0, 1-2, and ≥3. We defined hyperlipidemia as total cholesterol (TC) ≥ 5.17 mmol/L or triglycerides (TG) ≥ 1.7 mmol/L or low-density lipoprotein (LDL) cholesterol ≥ 3.37 mmol/L or a self-report of physician-diagnosed hyperlipidemia during follow-up visits. Cox proportional-hazards regression models were employed to assess the relationship between the number of missing teeth and incident hyperlipidemia.<BR><B>UNASSIGNED: </B>A total of 6756 first-incident cases of hyperlipidemia occurred during 42,048 person-years of follow-up (median follow-up, 4.2 years). After adjusted confounders, multivariable HRs and 95% CI for incident of hyperlipidemia across the categories of missing teeth were as follows: in male participants, 1.00 (reference), 1.10 (0.98, 1.22), and 1.03 (0.91, 1.16) (P for trend = 0.30); in female participants, 1.00 (reference), 1.09 (0.99, 1.19), and 1.18 (1.04, 1.33) (P for trend < 0.01).<BR><B>UNASSIGNED: </B>The number of missing teeth is associated with an increased risk of hyperlipidemia in female participants but not in male participants. Systemic chronic inflammation may potentially mediate this association.