Following application of either a 0.1% capsaicin or control cream to the upper and lower extremities (10 g total, ∼40-50% body surface area), 11 participants in shorts and a t-shirt were exposed to 30 min of cold (0 °C, 40% relative humidity). Exposures comprised of 5 min seated rest, 20 min walking (1.6 m·s-1, 5% grade), and 5 min seated rest. Temperature (skin, core), SkBF, skin conductivity, heart rate, thermal sensation, and thermal comfort were measured throughout.
The capsaicin treatment did not differ from the control treatment in skin temperature (treatment mean: 30.0 ± 2.5, 30.1 ± 2.4 °C, respectively, p = 0.655), core temperature (treatment mean: 37.3 ± 0.5, 37.4 ± 0.4 °C, respectively, p = 0.113), SkBF (treatment mean: -8.4 ± 10.0, -11.1 ± 10.7 A.U., respectively, p = 0.492), skin conductivity (treatment mean: -0.7 ± 5.1, 0.4 ± 6.4 µS, respectively, p = 0.651), or heart rate (treatment mean: 83 ± 29, 85 ± 28 beats·minute-1, respectively, p = 0.234). The capsaicin and control treatments also did not differ in thermal sensation (p = 0.521) and thermal comfort (p = 0.982), with perceptual outcomes corresponding with feeling \"cool\" and \"just uncomfortable,\" respectively.
0.1% topical capsaicin application to exposed limbs prior to walking in a cold environment does not alter whole-body thermoregulation or thermal perception.
方法:在上肢和下肢涂抹0.1%辣椒素或对照乳膏(共10g,〜40-50%的身体表面积),11名穿着短裤和T恤的参与者暴露于30分钟的寒冷中(0°C,40%相对湿度)。暴露包括5分钟坐着休息,步行20分钟(1.6m·s-1,5%坡度),和5分钟坐着休息。温度(皮肤,core),SkBF,皮肤导电性,心率,热感觉,并在整个过程中测量热舒适度。
结果:辣椒素治疗与对照治疗的皮肤温度没有差异(治疗平均值:30.0±2.5,30.1±2.4°C,分别,p=0.655),核心温度(处理平均值:37.3±0.5,37.4±0.4°C,分别,p=0.113),SkBF(治疗平均值:-8.4±10.0,-11.1±10.7A.U.,分别,p=0.492),皮肤电导率(治疗平均值:-0.7±5.1,0.4±6.4µS,分别,p=0.651),或心率(治疗平均值:83±29,85±28次·分钟-1,p=0.234)。辣椒素和对照治疗在热感觉(p=0.521)和热舒适(p=0.982)方面也没有差异,感知结果与感觉“酷”和“只是不舒服”相对应,\"分别。
结论:在寒冷环境中行走前,对暴露的四肢局部应用0.1%辣椒素不会改变全身的体温调节或热感知。