Abstract：
Capsaicin, a chili pepper extract, can stimulate increased skin blood flow (SkBF) with a perceived warming sensation on application areas. Larger surface area application may exert a more systemic thermoregulatory response. Capsaicin could assist with maintaining heat transport to the distal extremities, minimizing cold weather injury risk. However, the thermoregulatory and perceptual impact of topical capsaicin cream application prior to exercise in the cold is unknown.
Following application of either a 0.1% capsaicin or control cream to the upper and lower extremities (10 g total, ∼40-50% body surface area), 11 participants in shorts and a t-shirt were exposed to 30 min of cold (0 °C, 40% relative humidity). Exposures comprised of 5 min seated rest, 20 min walking (1.6 m·s-1, 5% grade), and 5 min seated rest. Temperature (skin, core), SkBF, skin conductivity, heart rate, thermal sensation, and thermal comfort were measured throughout.
The capsaicin treatment did not differ from the control treatment in skin temperature (treatment mean: 30.0 ± 2.5, 30.1 ± 2.4 °C, respectively, p = 0.655), core temperature (treatment mean: 37.3 ± 0.5, 37.4 ± 0.4 °C, respectively, p = 0.113), SkBF (treatment mean: -8.4 ± 10.0, -11.1 ± 10.7 A.U., respectively, p = 0.492), skin conductivity (treatment mean: -0.7 ± 5.1, 0.4 ± 6.4 µS, respectively, p = 0.651), or heart rate (treatment mean: 83 ± 29, 85 ± 28 beats·minute-1, respectively, p = 0.234). The capsaicin and control treatments also did not differ in thermal sensation (p = 0.521) and thermal comfort (p = 0.982), with perceptual outcomes corresponding with feeling \"cool\" and \"just uncomfortable,\" respectively.
0.1% topical capsaicin application to exposed limbs prior to walking in a cold environment does not alter whole-body thermoregulation or thermal perception.
Following application of either a 0.1% capsaicin or control cream to the upper and lower extremities (10 g total, ∼40-50% body surface area), 11 participants in shorts and a t-shirt were exposed to 30 min of cold (0 °C, 40% relative humidity). Exposures comprised of 5 min seated rest, 20 min walking (1.6 m·s-1, 5% grade), and 5 min seated rest. Temperature (skin, core), SkBF, skin conductivity, heart rate, thermal sensation, and thermal comfort were measured throughout.
The capsaicin treatment did not differ from the control treatment in skin temperature (treatment mean: 30.0 ± 2.5, 30.1 ± 2.4 °C, respectively, p = 0.655), core temperature (treatment mean: 37.3 ± 0.5, 37.4 ± 0.4 °C, respectively, p = 0.113), SkBF (treatment mean: -8.4 ± 10.0, -11.1 ± 10.7 A.U., respectively, p = 0.492), skin conductivity (treatment mean: -0.7 ± 5.1, 0.4 ± 6.4 µS, respectively, p = 0.651), or heart rate (treatment mean: 83 ± 29, 85 ± 28 beats·minute-1, respectively, p = 0.234). The capsaicin and control treatments also did not differ in thermal sensation (p = 0.521) and thermal comfort (p = 0.982), with perceptual outcomes corresponding with feeling \"cool\" and \"just uncomfortable,\" respectively.
0.1% topical capsaicin application to exposed limbs prior to walking in a cold environment does not alter whole-body thermoregulation or thermal perception.
摘要：
背景：辣椒素，辣椒提取物,可以刺激增加的皮肤血流量（SkBF），并在应用领域感知到温暖的感觉。更大的表面积应用可以发挥更系统的体温调节响应。辣椒素可以帮助保持热量传输到远端，减少寒冷天气伤害的风险。然而,在寒冷运动前局部应用辣椒素乳膏的体温调节和知觉影响尚不清楚。
方法：在上肢和下肢涂抹0.1%辣椒素或对照乳膏（共10g，〜40-50%的身体表面积)，11名穿着短裤和T恤的参与者暴露于30分钟的寒冷中（0°C，40%相对湿度)。暴露包括5分钟坐着休息，步行20分钟(1.6m·s-1,5%坡度),和5分钟坐着休息。温度(皮肤，core),SkBF,皮肤导电性，心率,热感觉,并在整个过程中测量热舒适度。
结果：辣椒素治疗与对照治疗的皮肤温度没有差异（治疗平均值：30.0±2.5，30.1±2.4°C，分别,p=0.655),核心温度（处理平均值：37.3±0.5，37.4±0.4°C，分别,p=0.113)，SkBF（治疗平均值：-8.4±10.0，-11.1±10.7A.U.，分别,p=0.492),皮肤电导率（治疗平均值：-0.7±5.1，0.4±6.4µS，分别,p=0.651),或心率（治疗平均值：83±29，85±28次·分钟-1，p=0.234）。辣椒素和对照治疗在热感觉（p=0.521）和热舒适（p=0.982）方面也没有差异，感知结果与感觉“酷”和“只是不舒服”相对应，\"分别。
结论：在寒冷环境中行走前，对暴露的四肢局部应用0.1%辣椒素不会改变全身的体温调节或热感知。
方法：在上肢和下肢涂抹0.1%辣椒素或对照乳膏（共10g，〜40-50%的身体表面积)，11名穿着短裤和T恤的参与者暴露于30分钟的寒冷中（0°C，40%相对湿度)。暴露包括5分钟坐着休息，步行20分钟(1.6m·s-1,5%坡度),和5分钟坐着休息。温度(皮肤，core),SkBF,皮肤导电性，心率,热感觉,并在整个过程中测量热舒适度。
结果：辣椒素治疗与对照治疗的皮肤温度没有差异（治疗平均值：30.0±2.5，30.1±2.4°C，分别,p=0.655),核心温度（处理平均值：37.3±0.5，37.4±0.4°C，分别,p=0.113)，SkBF（治疗平均值：-8.4±10.0，-11.1±10.7A.U.，分别,p=0.492),皮肤电导率（治疗平均值：-0.7±5.1，0.4±6.4µS，分别,p=0.651),或心率（治疗平均值：83±29，85±28次·分钟-1，p=0.234）。辣椒素和对照治疗在热感觉（p=0.521）和热舒适（p=0.982）方面也没有差异，感知结果与感觉“酷”和“只是不舒服”相对应，\"分别。
结论：在寒冷环境中行走前，对暴露的四肢局部应用0.1%辣椒素不会改变全身的体温调节或热感知。
