PDF(Pubmed)
Abstract：
A 10-year-old neutered male Chihuahua presented with unilateral dental erosion that occurred after several months of oral medications mixed with honey. A pH test was performed on all oral medications administered to the dogs to determine the cause of enamel erosion. Among the medications, the only acidic medication was clopidogrel (pH 2.65). To evaluate the effect of clopidogrel on the tooth surface under the same conditions as in the present patient, an additional preliminary study was designed in which two extracted teeth of another dog were immersed in a clopidogrel-honey mixture or only in honey. After a 3-week soaking of the extracted tooth in the clopidogrel-honey mixture, field-emission scanning electron microscope analysis revealed a rougher surface, whereas energy-dispersive X-ray spectroscopy analysis showed a reduced Ca/C ratio compared to the control tooth. In this case, prolonged exposure of the tooth surface to clopidogrel may be a cause of dental erosion.
摘要：
一名10岁的绝育男性吉娃娃出现单侧牙齿侵蚀，这是在几个月的口服药物与蜂蜜混合后发生的。对给予狗的所有口服药物进行pH测试以确定牙釉质侵蚀的原因。在药物中，唯一的酸性药物是氯吡格雷(pH2.65).在与本患者相同的条件下，评估氯吡格雷对牙齿表面的影响，另一项初步研究是将另一只狗的两颗拔掉的牙齿浸入氯吡格雷-蜂蜜混合物或仅浸入蜂蜜中。拔牙在氯吡格雷-蜂蜜混合物中浸泡3周后，场发射扫描电子显微镜分析显示表面更粗糙，而能量色散X射线光谱分析显示，与对照牙齿相比，Ca/C比率降低。在这种情况下,牙齿表面长时间暴露于氯吡格雷可能是牙齿侵蚀的原因。
