Abstract：
Protein structure determination and prediction, active site detection, and protein sequence alignment techniques all exploit information about protein structure and structural relationships. For membrane proteins, however, there is limited agreement among available online tools for highlighting and mapping such structural similarities. Moreover, no available resource provides a systematic overview of quaternary and internal symmetries, and their orientation relative to the membrane, despite the fact that these properties can provide key insights into membrane protein function and evolution. Here, we describe the Encyclopedia of Membrane Proteins Analyzed by Structure and Symmetry (EncoMPASS), a database for relating integral membrane proteins of known structure from the points of view of sequence, structure, and symmetry. EncoMPASS is accessible through a web interface, and its contents can be easily downloaded. This allows the user not only to focus on specific proteins, but also to study general properties of the structure and evolution of membrane proteins.
摘要：
蛋白质结构测定与预测,活性位点检测，和蛋白质序列比对技术都利用有关蛋白质结构和结构关系的信息。对于膜蛋白，然而,在突出和绘制这种结构相似性的可用在线工具之间的协议有限。此外，没有可用的资源提供四元和内部对称性的系统概述，以及它们相对于薄膜的方向，尽管这些特性可以为膜蛋白功能和进化提供关键见解。这里,我们描述了通过结构和对称性分析的膜蛋白百科全书（EncoMPASS），从序列的角度来关联已知结构的完整膜蛋白的数据库，结构,和对称性。可以通过Web界面访问EncoMPASS，它的内容可以很容易地下载。这允许用户不仅专注于特定的蛋白质，还要研究膜蛋白的结构和进化的一般性质。
