METHODS: This is a cross-sectional study. The study included 103 eyes with non-high myopia and 206 eyes with high myopia (139 with simple high myopia and 67 with pathological myopia). Macular structural and microcirculation parameters were determined using optical coherence tomography angiography (OCTA). The FAZ morphological parameters were measured manually using Image J software. Correlations between pathological myopia and various factors were analyzed.
RESULTS: Patients with pathological myopia had a thinner retinal thickness (RT) and choroidal thickness (CT) and a lower retinal superficial vascular density (SVD), retinal deep vascular complex density (DVD), choriocapillaris perfusion area (CCPA), and choroidal vascularity index (CVI) (all P < 0.05). Patients with pathological myopia had a larger FAZ area, perimeter, major axis, minor axis, acircularity index (AI), and lower circularity index (CI) (all P < 0.01). The axial length (AL), the major axis of the superficial FAZ, CI, and AI were significantly correlated with myopia severity (all P < 0.05).
CONCLUSIONS: Patients with pathological myopia exhibited worse macular microcirculation and thinner macular retina and choroid. The FAZ in pathological myopia was larger and more irregular. The AL, CI, and AI were significantly associated with myopia severity. Thus, CI and AI might serve as new indicators for monitoring the progression of myopia. Further investigations should be performed.
BACKGROUND: Clinical Trials.gov Identifier: ChiCTR2100046590.
方法:这是一项横断面研究。研究纳入非高度近视103只眼和高度近视206只眼(单纯高度近视139只眼和病理性近视67只眼)。使用光学相干断层扫描血管造影(OCTA)确定黄斑结构和微循环参数。使用ImageJ软件手动测量FAZ形态参数。分析病理性近视与各因素的相关性。
结果:病理性近视患者的视网膜厚度(RT)和脉络膜厚度(CT)较薄,视网膜浅层血管密度(SVD)较低,视网膜深血管复合密度(DVD),脉络膜毛细血管灌注区(CCPA),脉络膜血管指数(CVI)(均P<0.05)。病理性近视患者FAZ面积较大,周边,主轴,短轴,不规则性指数(AI),圆度指数(CI)较低(均P<0.01)。轴向长度(AL),表面FAZ的主轴,CI和AI与近视严重程度显著相关(均P<0.05)。
结论:病理性近视患者的黄斑微循环更差,黄斑视网膜和脉络膜变薄。病理性近视的FAZ较大且不规则。AL,CI和AI与近视严重程度显著相关。因此,CI和AI可能成为监测近视进展的新指标。应该进行进一步的调查。
背景:临床试验.gov标识符:ChiCTR2100046590。