PDF(Pubmed)
Abstract：
BACKGROUND: Neonatal septic meningitis is a serious condition that can be caused by various pathogens, including Corynebacterium aurimucosum, a rare and opportunistic bacterium. We reports a case of infectious meningitis in a premature infant with neonatal lupus erythematosus caused by C aurimucosum. The purpose of this study is to explore the occurrence of meningitis caused by C aurimucosum in preterm infants with neonatal lupus erythematosus. We found that early diagnosis and treatment are crucial for this type of meningitis, especially for infants with impaired immunity or mothers receiving immunosuppressive therapy. This bacterium is rare in clinical practice, but it needs to be taken seriously.
METHODS: The infant was born to a mother with systemic lupus erythematosus who had a history of long-term immunosuppressive therapy. The infant presented with preterm birth, purplish-red skin, fever, and widespread scarlet dermatitis. He also had positive anti-Ro/SSA and anti-La/SSB antibodies.
METHODS: The infant was diagnosed with neonatal lupus erythematosus based on clinical and serological features. A lumbar puncture revealed septic meningitis with high levels of total nucleated cells, protein, and Pan\'s test in the CSF. The macrogenic examination identified C aurimucosum as the causative agent. The culture of the mother\'s vaginal secretion also revealed the same bacterium.
METHODS: The infant was treated with anti-infective therapy with ceftriaxone, ampicillin, vancomycin, and meropenem. He also received prednisone and gammaglobulin infusion for neonatal lupus erythematosus.
RESULTS: The infant\'s temperature returned to normal, and his general condition and responsiveness improved. The CSF cytology and biochemistry normalized, and the culture was negative. The cranial MRI examination showed no abnormalities. The red rash disappeared, and the follow-ups after discharge revealed no complications.
CONCLUSIONS: This case highlights the importance of early diagnosis and treatment of neonatal septic meningitis caused by C aurimucosum, especially in infants with immunocompromised conditions or maternal history of immunosuppressive therapy. C aurimucosum should not be overlooked as a potential pathogen in neonatal septic meningitis.
METHODS: The infant was born to a mother with systemic lupus erythematosus who had a history of long-term immunosuppressive therapy. The infant presented with preterm birth, purplish-red skin, fever, and widespread scarlet dermatitis. He also had positive anti-Ro/SSA and anti-La/SSB antibodies.
METHODS: The infant was diagnosed with neonatal lupus erythematosus based on clinical and serological features. A lumbar puncture revealed septic meningitis with high levels of total nucleated cells, protein, and Pan\'s test in the CSF. The macrogenic examination identified C aurimucosum as the causative agent. The culture of the mother\'s vaginal secretion also revealed the same bacterium.
METHODS: The infant was treated with anti-infective therapy with ceftriaxone, ampicillin, vancomycin, and meropenem. He also received prednisone and gammaglobulin infusion for neonatal lupus erythematosus.
RESULTS: The infant\'s temperature returned to normal, and his general condition and responsiveness improved. The CSF cytology and biochemistry normalized, and the culture was negative. The cranial MRI examination showed no abnormalities. The red rash disappeared, and the follow-ups after discharge revealed no complications.
CONCLUSIONS: This case highlights the importance of early diagnosis and treatment of neonatal septic meningitis caused by C aurimucosum, especially in infants with immunocompromised conditions or maternal history of immunosuppressive therapy. C aurimucosum should not be overlooked as a potential pathogen in neonatal septic meningitis.
摘要：
背景：新生儿化脓性脑膜炎是一种严重的疾病，可由各种病原体引起，包括金黄色棒状杆菌,一种罕见的机会性细菌。我们报告了一例由C引起的新生儿红斑狼疮的早产儿感染性脑膜炎。目的探讨早产儿合并新生儿红斑狼疮引起的C型脑膜炎的发生情况。我们发现早期诊断和治疗对这类脑膜炎至关重要，特别是对于免疫力受损的婴儿或接受免疫抑制治疗的母亲。这种细菌在临床实践中很少见，但需要认真对待.
方法：该婴儿的母亲患有系统性红斑狼疮，有长期免疫抑制治疗史。早产的婴儿，紫红色皮肤,发烧,和广泛的猩红色皮炎。他还具有阳性的抗Ro/SSA和抗La/SSB抗体。
方法：根据临床和血清学特征诊断为新生儿红斑狼疮。腰椎穿刺显示化脓性脑膜炎有高水平的总有核细胞，蛋白质，和潘的脑脊液测试。巨源检查确定了Caurimucosum为病原体。母亲阴道分泌物的培养也显示出相同的细菌。
方法：婴儿接受头孢曲松抗感染治疗，氨苄青霉素,万古霉素,还有美罗培南.他还接受了泼尼松和丙种球蛋白输注治疗新生儿红斑狼疮。
结果：婴儿体温恢复正常，他的一般状况和反应能力得到了改善。脑脊液细胞学和生物化学正常化，文化是消极的。头颅MRI检查未见异常。红疹消失了,出院后随访发现无并发症。
结论：此例病例突出了早期诊断和治疗由金葡菌引起的新生儿化脓性脑膜炎的重要性，特别是在患有免疫功能低下疾病或有免疫抑制治疗史的婴儿中。不应将金黄色葡萄球菌作为新生儿化脓性脑膜炎的潜在病原体。
方法：该婴儿的母亲患有系统性红斑狼疮，有长期免疫抑制治疗史。早产的婴儿，紫红色皮肤,发烧,和广泛的猩红色皮炎。他还具有阳性的抗Ro/SSA和抗La/SSB抗体。
方法：根据临床和血清学特征诊断为新生儿红斑狼疮。腰椎穿刺显示化脓性脑膜炎有高水平的总有核细胞，蛋白质，和潘的脑脊液测试。巨源检查确定了Caurimucosum为病原体。母亲阴道分泌物的培养也显示出相同的细菌。
方法：婴儿接受头孢曲松抗感染治疗，氨苄青霉素,万古霉素,还有美罗培南.他还接受了泼尼松和丙种球蛋白输注治疗新生儿红斑狼疮。
结果：婴儿体温恢复正常，他的一般状况和反应能力得到了改善。脑脊液细胞学和生物化学正常化，文化是消极的。头颅MRI检查未见异常。红疹消失了,出院后随访发现无并发症。
结论：此例病例突出了早期诊断和治疗由金葡菌引起的新生儿化脓性脑膜炎的重要性，特别是在患有免疫功能低下疾病或有免疫抑制治疗史的婴儿中。不应将金黄色葡萄球菌作为新生儿化脓性脑膜炎的潜在病原体。
