目的:比较交联透明质酸(xHyA)与釉基质蛋白(EMD)在牙周内缺损再生治疗后六个月的再生临床和影像学效果。
方法:将60例出现一个骨内缺损的患者随机分为对照组(EMD)和试验组(xHyA)。临床依恋水平(CAL)增加是主要结果,而口袋探测深度(PPD),牙龈衰退(REC),探查出血(BOP),全口斑块评分(FMPS),全口出血评分(FMBS),和射线照相参数,如缺陷深度(BC-BD),缺损宽度(DW)被认为是次要结果变量。在基线和6个月后记录参数。
结果:在6个月的随访中,54例患者可进行统计分析。在对照组和测试组中,在组内比较中,平均CAL增益具有统计学意义(p<0.001).48.1%的测试部位显示CAL增益≤2mm,而对照组为33.3%。在两组的组内比较中,平均PPD降低具有统计学显著性(p<0.001)。两组的平均REC增加相似:1.04±1.29mmvs1.11±1.22mm(测试与对照)。平均BC-BD,DW,FMPS,FMBS,BOP仅在组内比较中发生统计学上的显着变化,不在组间比较中。
结论:两种治疗方法,EMD和xHyA,与基线相比,6个月后的临床和影像学改善具有相似的统计学意义.
OBJECTIVE: To compare the regenerative clinical and radiographic effects of cross-linked hyaluronic acid (xHyA) with enamel matrix proteins (EMD) at six months after regenerative treatment of periodontal intrabony defects.
METHODS: Sixty patients presenting one intrabony defect each were randomly assigned into control (EMD) and test (xHyA) groups. Clinical attachment level (CAL) gain was the primary outcome, while pocket probing depth (PPD), gingival recession (REC), bleeding on probing (BOP), full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), and radiographic parameters such as defect depth (BC-BD), and defect width (DW) were considered secondary outcome variables. Parameters were recorded at baseline and after 6 months.
RESULTS: At the 6-month follow-up, 54 patients were available for statistical analysis. In the control and test groups, the mean CAL gain was statistically significant in the intragroup comparison (p < 0.001). 48.1% of test sites showed a CAL gain ≤ 2 mm compared with 33.3% of control sites. The mean PPD reduction was statistically significant in the intragroup comparison in both groups (p < 0.001). The mean REC increase was similar in the two groups: 1.04 ± 1.29 mm vs 1.11 ± 1.22 mm (test vs control). The mean BC-BD, DW, FMPS, FMBS, and BOP changed statistically significantly only in the intragroup comparison, not in the intergroup comparison.
CONCLUSIONS: Both treatments, EMD and xHyA, produced similar statistically significant clinical and radiographical improvements after six months when compared with baseline.