Abstract：
Juvenile xanthogranuloma is a benign self-limiting lesion commonly described in infants and young children. It most commonly involves the skin presenting as single or multiple yellowish-brown papules. Clinical scenario with the classic histomorphology showing histiocytic aggregates in the dermis with xanthomatous cytoplasm, toutan type giant cells, immunohistochemistry with positive CD68, CD163, factor XIIIa and negative CD1a and S-100 help in diagnosis. However, diagnosis becomes challenging with predominant systemic bone marrow involvement in post-B-lymphoblastic leukemia settings.
摘要：
幼年黄色肉芽肿是一种良性自限性病变，通常在婴幼儿中描述。最常见的是皮肤表现为单个或多个黄褐色丘疹。具有经典组织形态学的临床方案显示真皮中的组织细胞聚集体与黄瘤细胞质，图坦型巨细胞,CD68，CD163，XIIIa因子阳性和CD1a和S-100阴性的免疫组织化学有助于诊断。然而,在B淋巴细胞白血病后患者中,以全身骨髓受累为主的情况下,诊断变得具有挑战性.
