Abstract：
UNASSIGNED: Splenic sclerosing angiomatoid nodular transformation (SANT) is a rare benign nodular lesion in the red medulla of the spleen. In the past, SANT has not been consistently recognized as the name for this condition and was often misdiagnosed for other conditions. In recent years, SANT has been acknowledged by most scholars as multiple reports have been published.
UNASSIGNED: To assess the clinicopathological features of SANT to identify the histological characteristics of SANT to improve diagnosis and clinical treatment.
UNASSIGNED: We assessed 25 cases of SANT diagnosed at Zhongshan Hospital affiliated with Fudan University from September 2014 to October 2021, including 14 men and 11 women, aged 24-62 years old.
UNASSIGNED: Fourteen cases were complicated with benign tumors of the liver, pancreas, kidney, uterus, and prostate. One case was complicated with renal clear cell carcinoma, and one was complicated with hepatocellular carcinoma. The gross neoplasm is multinodular and well defined. Histologically, angiomatoid nodules are composed of fattened, round, or irregular blood vessels, with or without red blood cells in the lumen, with unequal red blood cell extravasation, and fibrocytes around the nodules. The hemangiomatous nodules were positive for CD31 and CD34, while the vascular wall smooth muscle cells and fibrocytes around the nodules were positive for SMA.
UNASSIGNED: The diagnosis of SANT requires a combination of immunohistochemical and histological features, and early splenectomy is crucial for treatment.
UNASSIGNED: To assess the clinicopathological features of SANT to identify the histological characteristics of SANT to improve diagnosis and clinical treatment.
UNASSIGNED: We assessed 25 cases of SANT diagnosed at Zhongshan Hospital affiliated with Fudan University from September 2014 to October 2021, including 14 men and 11 women, aged 24-62 years old.
UNASSIGNED: Fourteen cases were complicated with benign tumors of the liver, pancreas, kidney, uterus, and prostate. One case was complicated with renal clear cell carcinoma, and one was complicated with hepatocellular carcinoma. The gross neoplasm is multinodular and well defined. Histologically, angiomatoid nodules are composed of fattened, round, or irregular blood vessels, with or without red blood cells in the lumen, with unequal red blood cell extravasation, and fibrocytes around the nodules. The hemangiomatous nodules were positive for CD31 and CD34, while the vascular wall smooth muscle cells and fibrocytes around the nodules were positive for SMA.
UNASSIGNED: The diagnosis of SANT requires a combination of immunohistochemical and histological features, and early splenectomy is crucial for treatment.
摘要：
■脾硬化性血管瘤样结节性转化（SANT）是脾脏红色髓质中罕见的良性结节性病变。在过去,SANT一直没有被公认为这种情况的名称，并且经常被误诊为其他情况。近年来,SANT已被大多数学者认可，因为已经发表了多个报告。
■评估SANT的临床病理特征，以确定SANT的组织学特征，以改善诊断和临床治疗。
我们评估了2014年9月至2021年10月在复旦大学附属中山医院诊断的25例SANT患者，其中男性14例，女性11例，年龄24-62岁。
■14例合并肝脏良性肿瘤，胰腺,肾,子宫,还有前列腺.1例并发肾透明细胞癌，其中一人并发肝细胞癌。大体肿瘤是多结节且明确定义的。组织学上,血管瘤样结节由发胖，圆形,或者不规则的血管，腔内有或没有红细胞，红细胞外渗不均匀，和结节周围的纤维细胞。血管瘤结节CD31和CD34阳性，而结节周围的血管壁平滑肌细胞和纤维细胞SMA阳性。
■SANT的诊断需要结合免疫组织化学和组织学特征，早期脾切除对治疗至关重要。
■评估SANT的临床病理特征，以确定SANT的组织学特征，以改善诊断和临床治疗。
我们评估了2014年9月至2021年10月在复旦大学附属中山医院诊断的25例SANT患者，其中男性14例，女性11例，年龄24-62岁。
■14例合并肝脏良性肿瘤，胰腺,肾,子宫,还有前列腺.1例并发肾透明细胞癌，其中一人并发肝细胞癌。大体肿瘤是多结节且明确定义的。组织学上,血管瘤样结节由发胖，圆形,或者不规则的血管，腔内有或没有红细胞，红细胞外渗不均匀，和结节周围的纤维细胞。血管瘤结节CD31和CD34阳性，而结节周围的血管壁平滑肌细胞和纤维细胞SMA阳性。
■SANT的诊断需要结合免疫组织化学和组织学特征，早期脾切除对治疗至关重要。
