Abstract：
OBJECTIVE: The aim was to investigate the changes in optic nerve function that may help in the diagnosis of subclinical optic nerve involvement in patients with Behçet\'s disease (BD) and isolated optic disc (OD) hyperfluorescence in fluorescein angiography (FA).
METHODS: Three groups were formed; BD patients with isolated OD hyperfluorescence in FA, BD patients without ocular involvement (normal FA) and control group. A total of 88 eyes of 45 patients were included. The groups were compared in terms of OCT-RNFL, contrast sensitivity and VEP latency.
RESULTS: When the OCT-RNFL values were compared, there was a significant difference between the control group and Behçet\'s patients with normal FA. Contrast sensitivity values differed significantly among the groups, and the lowest mean contrast sensitivity was observed in the group with OD hyperfluorescence (p < 0.05).
CONCLUSIONS: As far as we know, this is the first publication that investigates optic nerve function in BD patients with isolated OD hyperfluorescence in FA. Assessment with FA of asymptomatic BD patients with visual complaints and low contrast sensitivity may be helpful at early detection of inflammatory optic neuropathy by close follow-up in patients with OD hyperfluorescence.
METHODS: Three groups were formed; BD patients with isolated OD hyperfluorescence in FA, BD patients without ocular involvement (normal FA) and control group. A total of 88 eyes of 45 patients were included. The groups were compared in terms of OCT-RNFL, contrast sensitivity and VEP latency.
RESULTS: When the OCT-RNFL values were compared, there was a significant difference between the control group and Behçet\'s patients with normal FA. Contrast sensitivity values differed significantly among the groups, and the lowest mean contrast sensitivity was observed in the group with OD hyperfluorescence (p < 0.05).
CONCLUSIONS: As far as we know, this is the first publication that investigates optic nerve function in BD patients with isolated OD hyperfluorescence in FA. Assessment with FA of asymptomatic BD patients with visual complaints and low contrast sensitivity may be helpful at early detection of inflammatory optic neuropathy by close follow-up in patients with OD hyperfluorescence.
摘要：
目的：目的是研究视神经功能的变化，这些变化可能有助于诊断患有Behçet病（BD）和孤立性视盘（OD）的患者的亚临床视神经受累荧光素血管造影（FA）。
方法：形成三组；BD患者在FA中具有孤立的OD强荧光，无眼部受累的BD患者(FA正常)和对照组。共纳入45例患者的88只眼。比较各组OCT-RNFL,对比敏感度和VEP潜伏期。
结果：当比较OCT-RNFL值时，对照组与正常FA的Behçet患者之间存在显着差异。对比敏感度值在各组间差异显著,OD高荧光组平均对比敏感度最低(p<0.05)。
结论：据我们所知，这是第一份研究FA中孤立性OD强荧光的BD患者的视神经功能的出版物.对伴有视觉不适和对比敏感度低的无症状BD患者进行FA评估可能有助于通过对OD高荧光患者的密切随访来早期发现炎性视神经病变。
方法：形成三组；BD患者在FA中具有孤立的OD强荧光，无眼部受累的BD患者(FA正常)和对照组。共纳入45例患者的88只眼。比较各组OCT-RNFL,对比敏感度和VEP潜伏期。
结果：当比较OCT-RNFL值时，对照组与正常FA的Behçet患者之间存在显着差异。对比敏感度值在各组间差异显著,OD高荧光组平均对比敏感度最低(p<0.05)。
结论：据我们所知，这是第一份研究FA中孤立性OD强荧光的BD患者的视神经功能的出版物.对伴有视觉不适和对比敏感度低的无症状BD患者进行FA评估可能有助于通过对OD高荧光患者的密切随访来早期发现炎性视神经病变。
