PDF(Pubmed)
Abstract：
Anaesthesiologists commonly use intravenous labetalol to adjust patient haemodynamics during surgical procedures. Cases of profound hypotension after continuous labetalol infusions have been reported; however, there is limited evidence regarding the safety of intraoperative labetalol boluses. This audit examined the frequency of postoperative hypotension and bradycardia in 292 adult non-cardiac surgery patients treated with intraoperative labetalol boluses. Blood pressure and heart rate data were collected from the post-anaesthesia care unit and on the floor units for 24 hours after surgery. The median total intraoperative labetalol dose was 10mg. A total of 30/292 patients had all-cause postoperative hypotension within 24 hours of surgery, 26 of which had other medical or surgical precipitants. Fifteen patients developed bradycardia. There were no deaths or intensive care unit admissions attributed to labetalol. This audit demonstrates a low risk of all-cause postoperative hypotension (10%) and bradycardia (5%) after the use of small IV doses of intraoperative labetalol.
摘要：
麻醉医师通常使用静脉注射拉贝洛尔来调整患者在外科手术期间的血流动力学。据报道，连续输注拉贝洛尔后出现严重低血压的病例；然而，关于术中拉贝洛尔推注安全性的证据有限.本审核检查了292例接受术中拉贝洛尔推注治疗的成人非心脏手术患者的术后低血压和心动过缓的频率。手术后24小时从麻醉后护理单元和地板单元收集血压和心率数据。术中拉贝洛尔总剂量中位数为10mg。共有30/292例患者在术后24小时内出现全因术后低血压，其中26个有其他医疗或手术沉淀。15例患者出现心动过缓。没有死亡或重症监护病房入院归因于拉贝洛尔。这项审计表明，使用小剂量的术中拉贝洛尔后，全因术后低血压（10％）和心动过缓（5％）的风险较低。
