Abstract：
METHODS: Plant (poly) phenolic compounds have been reported to decrease the risk of developing dementia and have been associated with maintenance of cognitive performance in normal ageing. Ferulic acid (FA) is a phenolic acid, present in a wide variety of foods including cereals, fruits, vegetables, and coffee. The aim of this systematic review is to examine the effect of FA on cognitive function in humans and animals.
RESULTS: The search terms \"Ferulic acid AND cognit*\" and \"Ferulic acid OR feruloyl OR ferula AND (memory OR attention OR learning OR recognition)\" are used in Web of Science, Scopus, PubMED, OVID (Medline/PsycInfo), and CINAHL through October 2023. No human studies are identified that matched the inclusion criteria. Twenty-six animal studies are identified. A small number (n = 5) of these studies examined FA in healthy animals whilst the remainder examined animal models of dementia. Alzheimer\'s disease (n = 11) is the most prevalent model.
CONCLUSIONS: Overall, results from studies employing disease models suggest that FA ameliorates induced cognitive decline in a time and dose-dependent manner. Similarly, studies in healthy animals show a beneficial effect of FA. However, further studies are required to determine the effects of FA on human cognitive function.
RESULTS: The search terms \"Ferulic acid AND cognit*\" and \"Ferulic acid OR feruloyl OR ferula AND (memory OR attention OR learning OR recognition)\" are used in Web of Science, Scopus, PubMED, OVID (Medline/PsycInfo), and CINAHL through October 2023. No human studies are identified that matched the inclusion criteria. Twenty-six animal studies are identified. A small number (n = 5) of these studies examined FA in healthy animals whilst the remainder examined animal models of dementia. Alzheimer\'s disease (n = 11) is the most prevalent model.
CONCLUSIONS: Overall, results from studies employing disease models suggest that FA ameliorates induced cognitive decline in a time and dose-dependent manner. Similarly, studies in healthy animals show a beneficial effect of FA. However, further studies are required to determine the effects of FA on human cognitive function.
摘要：
方法：据报道，植物（多）酚类化合物可降低患痴呆症的风险，并与正常衰老时认知能力的维持有关。阿魏酸（FA）是一种酚酸，存在于各种各样的食物中，包括谷物，水果,蔬菜,和咖啡。本系统综述的目的是研究FA对人类和动物认知功能的影响。
结果：在WebofScience中使用了搜索术语“阿魏酸和Cognit*”和“阿魏酸或阿魏酸或阿魏酸和（记忆或注意力或学习或识别）”，Scopus,PubMED,OVID（Medline/PsycInfo），和CINAHL至2023年10月。没有发现符合纳入标准的人体研究。确定了26项动物研究。这些研究中的少量(n=5)检查了健康动物中的FA,而其余的检查了痴呆的动物模型。阿尔茨海默病(n=11)是最普遍的模型。
结论：总体而言，使用疾病模型的研究结果表明,FA以时间和剂量依赖性方式改善了诱导的认知功能下降.同样，对健康动物的研究表明FA的有益作用。然而,需要进一步的研究来确定FA对人类认知功能的影响。
结果：在WebofScience中使用了搜索术语“阿魏酸和Cognit*”和“阿魏酸或阿魏酸或阿魏酸和（记忆或注意力或学习或识别）”，Scopus,PubMED,OVID（Medline/PsycInfo），和CINAHL至2023年10月。没有发现符合纳入标准的人体研究。确定了26项动物研究。这些研究中的少量(n=5)检查了健康动物中的FA,而其余的检查了痴呆的动物模型。阿尔茨海默病(n=11)是最普遍的模型。
结论：总体而言，使用疾病模型的研究结果表明,FA以时间和剂量依赖性方式改善了诱导的认知功能下降.同样，对健康动物的研究表明FA的有益作用。然而,需要进一步的研究来确定FA对人类认知功能的影响。
