RESULTS: The search terms \"Ferulic acid AND cognit*\" and \"Ferulic acid OR feruloyl OR ferula AND (memory OR attention OR learning OR recognition)\" are used in Web of Science, Scopus, PubMED, OVID (Medline/PsycInfo), and CINAHL through October 2023. No human studies are identified that matched the inclusion criteria. Twenty-six animal studies are identified. A small number (n = 5) of these studies examined FA in healthy animals whilst the remainder examined animal models of dementia. Alzheimer\'s disease (n = 11) is the most prevalent model.
CONCLUSIONS: Overall, results from studies employing disease models suggest that FA ameliorates induced cognitive decline in a time and dose-dependent manner. Similarly, studies in healthy animals show a beneficial effect of FA. However, further studies are required to determine the effects of FA on human cognitive function.
结果:在WebofScience中使用了搜索术语“阿魏酸和Cognit*”和“阿魏酸或阿魏酸或阿魏酸和(记忆或注意力或学习或识别)”,Scopus,PubMED,OVID(Medline/PsycInfo),和CINAHL至2023年10月。没有发现符合纳入标准的人体研究。确定了26项动物研究。这些研究中的少量(n=5)检查了健康动物中的FA,而其余的检查了痴呆的动物模型。阿尔茨海默病(n=11)是最普遍的模型。
结论:总体而言,使用疾病模型的研究结果表明,FA以时间和剂量依赖性方式改善了诱导的认知功能下降.同样,对健康动物的研究表明FA的有益作用。然而,需要进一步的研究来确定FA对人类认知功能的影响。