Abstract：
OBJECTIVE: We aimed to compare the detectability of optic disc drusen (ODD), using various non-invasive imaging techniques, including the novel retro-mode imaging (RMI), as well as to analyze the morphological characteristics of ODD on RMI.
METHODS: This study involved seven patients with bilateral ODD, totaling 14 eyes. Multimodal imaging techniques, including multicolor fundus photography (MC), near-infrared reflectance (NIR), green and blue light fundus autofluorescence (G-FAF and B-FAF, respectively), and RMI were used to examine the eyes. FAF was used as the primary method of identifying ODD, and each method\'s detection rate was compared by two observers. Quantitative measurements of ODD included the number of ODD visualized by the RMI technique, the perimeter (P) and area (A) of ODD were identified.
RESULTS: The average age of the patients included was 49.28 ± 23.16 years, with five of the seven being men. RMI was able to detect ODD in all cases, with a sensitivity of 100%, compared to MC (sensitivity 60.71%), NIR (sensitivity 60.71%), B-FAF (sensitivity 100%), G-FAF (sensitivity 100%). RMI was the only imaging technique capable of assessing ODD morphology and quantifying ODD.
CONCLUSIONS: RMI is a promising imaging modality for diagnosing superficial ODD, providing valuable information on the distribution, location, and size of ODD. We suggest the incorporation of RMI as a complementary tool for diagnosing and monitoring ODD in combination with other multimodal imaging methods.
METHODS: This study involved seven patients with bilateral ODD, totaling 14 eyes. Multimodal imaging techniques, including multicolor fundus photography (MC), near-infrared reflectance (NIR), green and blue light fundus autofluorescence (G-FAF and B-FAF, respectively), and RMI were used to examine the eyes. FAF was used as the primary method of identifying ODD, and each method\'s detection rate was compared by two observers. Quantitative measurements of ODD included the number of ODD visualized by the RMI technique, the perimeter (P) and area (A) of ODD were identified.
RESULTS: The average age of the patients included was 49.28 ± 23.16 years, with five of the seven being men. RMI was able to detect ODD in all cases, with a sensitivity of 100%, compared to MC (sensitivity 60.71%), NIR (sensitivity 60.71%), B-FAF (sensitivity 100%), G-FAF (sensitivity 100%). RMI was the only imaging technique capable of assessing ODD morphology and quantifying ODD.
CONCLUSIONS: RMI is a promising imaging modality for diagnosing superficial ODD, providing valuable information on the distribution, location, and size of ODD. We suggest the incorporation of RMI as a complementary tool for diagnosing and monitoring ODD in combination with other multimodal imaging methods.
摘要：
目的：我们旨在比较视盘玻璃疣（ODD）的可检测性，使用各种非侵入性成像技术，包括新颖的后向模式成像（RMI），以及分析RMI上ODD的形态特征。
方法：本研究涉及7例双侧ODD患者，共14只眼睛。多模态成像技术,包括多色眼底摄影（MC），近红外反射(NIR),绿色和蓝色光眼底自发荧光(G-FAF和B-FAF，分别)，和RMI用于检查眼睛。FAF被用作识别ODD的主要方法，并由两名观察者比较每种方法的检出率。ODD的定量测量包括通过RMI技术可视化的ODD数量，确定了ODD的周长（P）和面积（A）。
结果：纳入患者的平均年龄为49.28±23.16岁，七个人中有五个是男人。RMI能够在所有情况下检测到ODD，灵敏度为100%，与MC(灵敏度60.71%)相比，NIR（灵敏度60.71%），B-FAF(灵敏度100%),G-FAF(灵敏度100%)。RMI是唯一能够评估ODD形态和量化ODD的成像技术。
结论：RMI是诊断浅表ODD的一种有前途的影像学方法，提供有价值的信息，location,和ODD的大小。我们建议结合其他多模态成像方法，将RMI作为诊断和监测ODD的补充工具。
方法：本研究涉及7例双侧ODD患者，共14只眼睛。多模态成像技术,包括多色眼底摄影（MC），近红外反射(NIR),绿色和蓝色光眼底自发荧光(G-FAF和B-FAF，分别)，和RMI用于检查眼睛。FAF被用作识别ODD的主要方法，并由两名观察者比较每种方法的检出率。ODD的定量测量包括通过RMI技术可视化的ODD数量，确定了ODD的周长（P）和面积（A）。
结果：纳入患者的平均年龄为49.28±23.16岁，七个人中有五个是男人。RMI能够在所有情况下检测到ODD，灵敏度为100%，与MC(灵敏度60.71%)相比，NIR（灵敏度60.71%），B-FAF(灵敏度100%),G-FAF(灵敏度100%)。RMI是唯一能够评估ODD形态和量化ODD的成像技术。
结论：RMI是诊断浅表ODD的一种有前途的影像学方法，提供有价值的信息，location,和ODD的大小。我们建议结合其他多模态成像方法，将RMI作为诊断和监测ODD的补充工具。
