PDF(Pubmed)
Abstract：
In this review, we explore the intriguing realm of neurogenesis in the vestibular nuclei-a critical brainstem region governing balance and spatial orientation. We retrace almost 20 years of research into vestibular neurogenesis, from its discovery in the feline model in 2007 to the recent discovery of a vestibular neural stem cell niche. We explore the reasons why neurogenesis is important in the vestibular nuclei and the triggers for activating the vestibular neurogenic niche. We develop the symbiotic relationship between neurogenesis and gliogenesis to promote vestibular compensation. Finally, we examine the potential impact of reactive neurogenesis on vestibular compensation, highlighting its role in restoring balance through various mechanisms.
摘要：
在这次审查中,我们探索了前庭核中神经发生的有趣领域-控制平衡和空间方向的关键脑干区域。我们回顾了近20年前庭神经发生的研究，从2007年在猫科动物模型中发现到最近发现的前庭神经干细胞生态位。我们探讨了神经发生在前庭核中重要的原因以及激活前庭神经发生生态位的触发因素。我们开发了神经发生和胶质发生之间的共生关系，以促进前庭代偿。最后,我们研究了反应性神经发生对前庭代偿的潜在影响，强调其通过各种机制恢复平衡的作用。
