■急性单侧前庭病(AUVP)是引起外周性前庭性眩晕的第二大原因。AUVP的完全恢复与足够的中央前庭代偿有关。现已证实,前庭核和前庭皮质介入了AUVP患者的前庭代偿进程。然而,很少有研究关注AUVP患者的丘脑功能代偿。本研究旨在探讨AUVP患者使用功能磁共振成像(fMRI)对丘脑静息状态功能连接(FC)的改变。
■从40名AUVP患者和35名健康对照(HC)收集3D-T1和静息状态fMRI数据。分析基于种子的(双侧丘脑)FC,以调查两组之间FC的变化。此外,我们使用Pearson的部分相关性评估了AUVP患者丘脑FC改变与临床特征之间的关联.
■与HC相比,AUVP患者显示双侧丘脑和左岛之间的FC降低。我们还观察到右丘脑和左缘上回之间的FC降低。此外,我们发现左丘脑和右中央后回(PCG)之间的FC增加,以及右丘脑和双侧PCG区域之间的FC增加,AUVP患者的右中额回和右中枕回。此外,AUVP患者左丘脑和左岛之间的FC与管麻痹值呈负相关(p=0.010,r=-0.434)。
■我们的结果为丘脑-前庭皮质通路减少提供了第一个证据,以及AUVP患者的丘脑-体感和丘脑-视觉皮层通路增加。这些发现有助于我们更好地了解急性单侧外周前庭损伤后中枢动态代偿的潜在机制。
UNASSIGNED: Acute unilateral vestibulopathy (AUVP) is the second leading cause of peripheral vestibular vertigo. Full recovery of AUVP is related to sufficient central vestibular compensation. It has been confirmed that the vestibular nucleus and vestibular cortex are involved in the process of vestibular compensatory in AUVP patients. However, few studies have focused on the functional compensation of thalamus in patients with AUVP. This study aimed to explore the alterations of resting-state functional connectivity (FC) focused on thalamus using functional magnetic resonance imaging (fMRI) in AUVP patients.
UNASSIGNED: Data of 3D-T1 and resting-state fMRI were collected from 40 AUVP patients and 35 healthy controls (HC). Seeds-based (bilateral thalamus) FC was analyzed to investigate the changes in FC between the two groups. Furthermore, we evaluated the associations between altered thalamus FC and clinical features in AUVP patients using Pearson\'s partial correlation.
UNASSIGNED: Compared with HC, AUVP patients showed decreased FC between bilateral thalamus and left insula. We also observed decreased FC between right thalamus and left supramarginal gyrus. Additionally, we found increased FC between left thalamus and right postcentral gyrus (PCG), as well as increased FC between right thalamus and regions of bilateral PCG, right middle frontal gyrus and right middle occipital gyrus in AUVP patients. Furthermore, the FC between left thalamus and left insula was negatively correlated with values of canal paresis in patients with AUVP (p = 0.010, r = -0.434).
UNASSIGNED: Our results provided first evidence for the decreased thalamo-vestibular cortex pathway, as well as increased thalamo-somatosensory and thalamo-visual cortex pathway in AUVP patients. These findings help us better understand the underlying mechanisms of central dynamic compensatory following an acute unilateral peripheral vestibular damage.