PDF(Pubmed)
Abstract：
We aimed to explore the value of magnetoencephalography in the presurgical evaluation of patients with posterior cortex epilepsy.
A total of 39 patients with posterior cortex epilepsy (PCE) and intact magnetoencephalography (MEG) images were reviewed from August 2019 to July 2022. MEG dipole clusters were classified into single clusters, multiple clusters, and scatter dipoles based on tightness criteria. The association of the surgical outcome with MEG dipole classifications was evaluated using Fisher\'s exact tests.
Among the 39 cases, there were 24 cases of single clusters (61.5%), nine cases of multiple clusters (23.1%), and six cases of scattered dipoles (15.4%). Patients with single dipole clusters were more likely to become seizure-free. Among single dipole cluster cases (n = 24), complete MEG dipole resection yielded a more favorable surgical outcome than incomplete resection (83.3% vs. 16.7%, p = 0.007). Patients with concordant MRI and MEG findings achieved a significantly more favorable surgical outcome than discordant patients (66.7% vs. 33.3%, p = 0.044), especially in single dipole cluster patients (87.5% vs. 25.0%, p = 0.005).
MEG can provide additional valuable information regarding surgical candidate selection, epileptogenic zone localization, electrode implantation schedule, and final surgical planning in patients with posterior cortex epilepsy.
A total of 39 patients with posterior cortex epilepsy (PCE) and intact magnetoencephalography (MEG) images were reviewed from August 2019 to July 2022. MEG dipole clusters were classified into single clusters, multiple clusters, and scatter dipoles based on tightness criteria. The association of the surgical outcome with MEG dipole classifications was evaluated using Fisher\'s exact tests.
Among the 39 cases, there were 24 cases of single clusters (61.5%), nine cases of multiple clusters (23.1%), and six cases of scattered dipoles (15.4%). Patients with single dipole clusters were more likely to become seizure-free. Among single dipole cluster cases (n = 24), complete MEG dipole resection yielded a more favorable surgical outcome than incomplete resection (83.3% vs. 16.7%, p = 0.007). Patients with concordant MRI and MEG findings achieved a significantly more favorable surgical outcome than discordant patients (66.7% vs. 33.3%, p = 0.044), especially in single dipole cluster patients (87.5% vs. 25.0%, p = 0.005).
MEG can provide additional valuable information regarding surgical candidate selection, epileptogenic zone localization, electrode implantation schedule, and final surgical planning in patients with posterior cortex epilepsy.
摘要：
目的：我们旨在探讨脑磁图在后皮质癫痫患者术前评估中的价值。
方法：回顾了2019年8月至2022年7月共39例后皮质癫痫（PCE）和完整脑磁图（MEG）图像。MEG偶极团簇分为单团簇，多个群集，和基于紧密度标准的散射偶极子。使用Fisher精确检验评估手术结果与MEG偶极分类的相关性。
结果：39例中，单簇24例(61.5%)，9例多簇病例(23.1%)，和6例分散偶极子(15.4%)。具有单个偶极簇的患者更有可能变得无癫痫发作。在单偶极团簇情况下(n=24)，完全MEG偶极切除比不完全切除产生更有利的手术结果(83.3%vs.16.7%,p=0.007)。MRI和MEG表现一致的患者比不一致的患者获得了更有利的手术结果（66.7％vs.33.3%,p=0.044),尤其是单偶极集群患者(87.5%vs.25.0%,p=0.005)。
结论：MEG可以提供关于手术候选者选择的更多有价值的信息，癫痫区定位,电极植入时间表，后皮质癫痫患者的最终手术计划。
方法：回顾了2019年8月至2022年7月共39例后皮质癫痫（PCE）和完整脑磁图（MEG）图像。MEG偶极团簇分为单团簇，多个群集，和基于紧密度标准的散射偶极子。使用Fisher精确检验评估手术结果与MEG偶极分类的相关性。
结果：39例中，单簇24例(61.5%)，9例多簇病例(23.1%)，和6例分散偶极子(15.4%)。具有单个偶极簇的患者更有可能变得无癫痫发作。在单偶极团簇情况下(n=24)，完全MEG偶极切除比不完全切除产生更有利的手术结果(83.3%vs.16.7%,p=0.007)。MRI和MEG表现一致的患者比不一致的患者获得了更有利的手术结果（66.7％vs.33.3%,p=0.044),尤其是单偶极集群患者(87.5%vs.25.0%,p=0.005)。
结论：MEG可以提供关于手术候选者选择的更多有价值的信息，癫痫区定位,电极植入时间表，后皮质癫痫患者的最终手术计划。
