PDF(Pubmed)
Abstract：
Excess oxidative stress generated in the body causes various types of cellular damage, including DNA damage. Certain trace minerals act as antioxidants by functioning as cofactors for antioxidant enzymes. This study was conducted to evaluate the serum and hair concentrations of major antioxidant trace minerals (zinc, manganese, selenium, and chromium) and to determine the association between the oxidative stress marker urinary 8-hydroxy-2\'-deoxyguanosine (8-OHdG) and serum or hair antioxidant trace mineral concentrations, according to the general characteristics of healthy adults. Study participants were selected after screening, and 108 participants aged 19-69 years were finally included. Serum and hair trace mineral concentrations were analyzed using inductively coupled plasma mass spectrometry, and urine 8-OHdG levels were quantified using an ELISA kit. Results showed that urinary 8-OHdG levels were significantly higher in exercisers than in those who did not exercise. Correlation analysis revealed that urinary 8-OHdG was negatively correlated with hair zinc in participants over 60 years of age and with poor health status, and positively correlated with hair chromium in participants with irregular dietary habits. In conclusion, these results suggest that urinary 8-OHdG is particularly correlated with hair zinc and chromium levels. Additional large-scale epidemiological studies are needed to generally confirm these findings.
摘要：
体内产生的过度氧化应激会导致各种类型的细胞损伤，包括DNA损伤.某些微量矿物质通过充当抗氧化酶的辅因子而充当抗氧化剂。进行这项研究以评估主要抗氧化剂痕量矿物质（锌，锰，硒,和铬），并确定氧化应激标志物尿8-羟基-2'-脱氧鸟苷（8-OHdG）与血清或头发抗氧化剂痕量矿物质浓度之间的关联，根据健康成年人的一般特征。筛选后选择研究参与者，108名年龄在19-69岁的参与者最终被纳入.使用电感耦合等离子体质谱法分析血清和头发痕量矿物质浓度，和尿8-OHdG水平使用ELISA试剂盒定量。结果表明，运动者的尿8-OHdG水平明显高于不运动者。相关分析显示，在60岁以上且健康状况较差的参与者中，尿8-OHdG与头发锌呈负相关。与有不规则饮食习惯的参与者的头发铬呈正相关。总之,这些结果表明，尿8-OHdG与头发锌和铬水平特别相关。需要额外的大规模流行病学研究来普遍证实这些发现。
