Abstract：
Response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro-inflammatory state appears to reduce neurogenesis, and has been associated with refractory depressive states. We propose to analyze the human neural progenitor cells derived from the olfactory epithelium (HNPCs-OE) as an indicator of neurogenesis in humans. Therefore, we compared the number and content of HNPCs-OE in depressed patients taking antidepressants, according to response to treatment. Twenty depressed patients were followed during eight weeks after antidepressant treatment was prescribed. At the end evaluation they were divided in two groups according to Hamilton depression rating scale (HDRS) scores: responders and non-responders. We compared the number and components of HNPCs-OE between groups and observed an elevation of interleukine-8 in those patients who do not achieve response to treatment, BDNF levels were no related to antidepressant response.
摘要：
对抗抑郁药的反应与海马神经发生的完整性有关，由神经营养因子介导的过程，例如脑源性神经营养因子(BDNF)。反过来,促炎状态似乎减少神经发生，并与难治性抑郁状态有关。我们建议分析源自嗅觉上皮（HNPCs-OE）的人类神经祖细胞，作为人类神经发生的指标。因此,我们比较了服用抗抑郁药的抑郁症患者中HNPCs-OE的数量和含量，根据对治疗的反应。在规定抗抑郁治疗后的八周内，对20名抑郁症患者进行了随访。在评估结束时，根据汉密尔顿抑郁量表（HDRS）评分将他们分为两组：响应者和非响应者。我们比较了各组间HNPCs-OE的数量和成分，并观察到白细胞介素-8在对治疗没有反应的患者中升高，BDNF水平与抗抑郁反应无关。
