{Reference Type}: Journal Article
{Title}: Relationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response.
{Author}: Mónica FR;Gerardo Bernabé RR;Rodrigo GZ;Melissa SB;Lorena RB;
{Journal}: J Psychiatr Res
{Volume}: 171
{Issue}: 0
{Year}: 2024 Mar 1
{Factor}: 5.25
{DOI}: 10.1016/j.jpsychires.2024.01.047
{Abstract}: Response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro-inflammatory state appears to reduce neurogenesis, and has been associated with refractory depressive states. We propose to analyze the human neural progenitor cells derived from the olfactory epithelium (HNPCs-OE) as an indicator of neurogenesis in humans. Therefore, we compared the number and content of HNPCs-OE in depressed patients taking antidepressants, according to response to treatment. Twenty depressed patients were followed during eight weeks after antidepressant treatment was prescribed. At the end evaluation they were divided in two groups according to Hamilton depression rating scale (HDRS) scores: responders and non-responders. We compared the number and components of HNPCs-OE between groups and observed an elevation of interleukine-8 in those patients who do not achieve response to treatment, BDNF levels were no related to antidepressant response.