Abstract：
Recent studies have shown that follicular helper T-cell lymphoma of angioimmunoblastic type (AITL), the most common nodal peripheral T-cell lymphoma (PTCL), frequently arises in a background of clonal haematopoiesis (CH), a preneoplastic condition affecting up to 40% of elderly individuals. Data on a potential CH association are limited for other PTCL. We report a unique patient who sequentially developed both cytotoxic PTCL, not otherwise specified and AITL with distinct T-cell receptor rearrangements but shared somatic mutations originating from the same CH clone, thus providing convincing evidence that CH can give rise to T-cell neoplasms of different lineage.
摘要：
最近的研究表明，血管免疫母细胞型滤泡辅助性T细胞淋巴瘤（AITL），最常见的淋巴结周围T细胞淋巴瘤（PTCL），经常出现在克隆造血（CH）的背景下，一种影响多达40%老年人的肿瘤前疾病。关于潜在CH关联的数据对于其他PTCL是有限的。我们报告了一位独特的患者，他依次发展了两种细胞毒性PTCL，未另作说明，AITL具有不同的T细胞受体重排，但共有源自同一CH克隆的体细胞突变，从而提供令人信服的证据表明CH可以引起不同谱系的T细胞肿瘤。
