%0 Case Reports
%T Clonal haematopoiesis: A common progenitor for cytotoxic peripheral T-cell lymphoma and angioimmunoblastic T-cell lymphoma.
%A Vogelsberg A
%A Harland L
%A Borgmann V
%A Otto F
%A Weller JF
%A Nann D
%A Quintanilla-Martinez L
%A Fend F
%J Br J Haematol
%V 204
%N 5
%D 2024 May 7
%M 38323682
%F 8.615
%R 10.1111/bjh.19335
%X Recent studies have shown that follicular helper T-cell lymphoma of angioimmunoblastic type (AITL), the most common nodal peripheral T-cell lymphoma (PTCL), frequently arises in a background of clonal haematopoiesis (CH), a preneoplastic condition affecting up to 40% of elderly individuals. Data on a potential CH association are limited for other PTCL. We report a unique patient who sequentially developed both cytotoxic PTCL, not otherwise specified and AITL with distinct T-cell receptor rearrangements but shared somatic mutations originating from the same CH clone, thus providing convincing evidence that CH can give rise to T-cell neoplasms of different lineage.