{Reference Type}: Case Reports
{Title}: Clonal haematopoiesis: A common progenitor for cytotoxic peripheral T-cell lymphoma and angioimmunoblastic T-cell lymphoma.
{Author}: Vogelsberg A;Harland L;Borgmann V;Otto F;Weller JF;Nann D;Quintanilla-Martinez L;Fend F;
{Journal}: Br J Haematol
{Volume}: 204
{Issue}: 5
{Year}: 2024 May 7
{Factor}: 8.615
{DOI}: 10.1111/bjh.19335
{Abstract}: Recent studies have shown that follicular helper T-cell lymphoma of angioimmunoblastic type (AITL), the most common nodal peripheral T-cell lymphoma (PTCL), frequently arises in a background of clonal haematopoiesis (CH), a preneoplastic condition affecting up to 40% of elderly individuals. Data on a potential CH association are limited for other PTCL. We report a unique patient who sequentially developed both cytotoxic PTCL, not otherwise specified and AITL with distinct T-cell receptor rearrangements but shared somatic mutations originating from the same CH clone, thus providing convincing evidence that CH can give rise to T-cell neoplasms of different lineage.