PDF(Pubmed)
Abstract：
The odontogenic keratocyst (OKC) is a benign but locally aggressive growing lesion that infiltrates the bone and surrounding tissue. It is characterized by high rates of recurrence along with rapid growth. Different forms of partly successful treatment therapies are reported. The retrospective study at hand examined 114 patients with OKC treated over a period of 20 years. Data extracted includes gender, age, location, previous treatment for the lesion, surgery, outcome, recurrence rate and follow-up. 63.1% of the patients underwent cystectomy, 22.5% by cystectomy and carnoy solution, 7.2% by cystectomy, and curettage, 4.5% by cystostomy and 2.7% by partial resection. In this study, no significant differences could be observed regarding the surgical method. Most recurrences occurred with 91.9% in the mandible with an average size of 5.5 cm2 and increased in women. Within a mean follow-up time of 3.6 years the recurrence rate was 36.9%, on average after 36 months. Recurrences were most frequently diagnosed at the age of 31-50 (43.9%). Despite numerous studies, there is still no unanimous opinion on an effective therapy for OKC. However, precise resection of OKC can be facilitated by preoperative 3D-imaging and virtual planning.
摘要：
牙源性角化囊肿（OKC）是一种良性但局部侵袭性生长的病变，可浸润骨骼和周围组织。它的特点是高复发率和快速增长。报道了不同形式的部分成功治疗疗法。这项回顾性研究检查了114例OKC患者在20年的时间内接受了治疗。提取的数据包括性别、年龄,location,先前对病变的治疗，手术,结果,复发率和随访。63.1%的患者行膀胱切除术,22.5％通过膀胱切除术和Carnoy解决方案，膀胱切除术7.2%，和刮宫,膀胱造瘘4.5%，部分切除2.7%。在这项研究中,在手术方法方面没有观察到显著差异.大多数复发发生在下颌骨中，占91.9％，平均大小为5.5cm2，女性则增加。在平均3.6年的随访时间内，复发率为36.9%，平均36个月后。复发最常诊断为31-50岁（43.9％）。尽管有大量的研究,对于OKC的有效治疗仍没有一致的意见。然而,术前3D成像和虚拟计划可以促进OKC的精确切除。
