METHODS: Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30, 90, and 180-min after each protocol to determine ischaemia modified albumin (IMA), neuron-specific enolase (NSE), myoglobin, and high sensitivity cardiac troponin T (hscTnT) concentrations.
RESULTS: IMA was elevated after the apnoeic interventions (STA,+86%;DYN,+332%,p ≤ 0.047) but not CTL (p = 0.385). Myoglobin was higher than baseline (23.6 ± 3.9 ng/mL) 30-min post DYN (+70%,38.8 ± 13.3 ng/mL,p = 0.030). A greater myoglobin release was recorded in DYN compared with STA and CTL (p ≤ 0.035). No changes were observed in NSE (p = 0.207) or hscTnT (p = 0.274).
CONCLUSIONS: Five repeated maximal DYN led to a greater muscle injury compared with STA but neither elicited myocardial injury or neuronal-parenchymal damage.
方法:11名健康男性在三个不同的场合进行(间隔≥72小时):一系列五次重复的最大(i)静态(STA)或(ii)动态呼吸暂停(DYN)或(iii)静态呼吸协议(CTL)。在每个方案后30、90和180分钟抽取静脉血样本,以确定缺血修饰的白蛋白(IMA)。神经元特异性烯醇化酶(NSE),肌红蛋白,和高灵敏度的心肌肌钙蛋白T(hscTnT)浓度。
结果:呼吸暂停干预后IMA升高(STA,+86%;DYN,+332%,p≤0.047),但不CTL(p=0.385)。肌红蛋白高于基线(23.6±3.9ng/mL)30分钟后DYN(+70%,38.8±13.3ng/mL,p=0.030)。与STA和CTL相比,DYN中的肌红蛋白释放更大(p≤0.035)。在NSE(p=0.207)或hscTnT(p=0.274)中未观察到变化。
结论:与STA相比,五次重复的最大DYN导致更大的肌肉损伤,但均未引起心肌损伤或神经元实质损伤。