PDF(Pubmed)
Abstract：
Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1-20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.
摘要：
丝状病毒科是一类负义RNA病毒，其基因组约为13.1-20.9kb，可感染鱼类，哺乳动物和爬行动物。丝状病毒基因组是线性的，具有五个编码核蛋白（NP）的规范开放阅读框（ORF）的非分段RNA，聚合酶辅因子（VP35），糖蛋白（GP1,2），转录激活因子(VP30)和含有RNA定向RNA聚合酶(RdRP)结构域的大蛋白(L)。所有丝状病毒基因组编码不同属的其他蛋白质。几个丝状动物(例如，埃博拉病毒,马尔堡病毒）对人类具有致病性，并且具有很强的毒力。这是国际病毒分类学委员会（ICTV）关于丝状病毒科的报告的摘要，可以在www上找到。ictv。全球/报告/丝状病毒科.
