■马尔堡病毒(MARV),埃博拉病毒的近亲,可以在高死亡率的人类中诱发出血热。近年来,由于在各个非洲国家中观察到的零星爆发,这种高度致命的病毒越来越受到关注。这种文献计量分析努力阐明趋势,动力学,以及描绘了有关MARV的研究景观的知识焦点。
■1968年至2023年有关MARV的相关文献是从WebofScienceCoreCollection数据库中提取的。在此之后,利用在线分析平台对数据进行了文献计量分析和可视化程序,CiteSpace6.2R6和VOSviewer1.6.20。三种不同类型的文献计量指标,包括定量指标,定性指标,结构指标被用来衡量研究人员的生产力,评估他们的工作质量,并分析出版关系,分别。
MARV主要在非洲流行。迄今为止,文献中已经描述了大约643例确诊病例,在总体患者中观察到的死亡率为81.2%.共纳入1014篇论文,包括869篇文章和145篇评论。年度出版物显示出从1968年到2023年的增长模式(R2=0.8838)。美国站在这个学科的前沿,拥有大量的财政和人力资源来进行科学调查。然而,合著者分析显示,国际研究合作有待进一步加强。基于参考和关键词分析,当代MARV研究涵盖了关键领域:主要是,优先考虑创建预防性疫苗以阻止病毒传播,其次,探索有针对性的抗病毒策略,包括小分子抗病毒药物或MARV特异性单克隆抗体。此外,全面掌握病毒传播,转录,复制机制仍然是正在进行的调查的中心重点。未来的MARV研究预计将侧重于评估临床试验的安全性和有效性,开发抑制病毒传播的抑制剂,探索疫苗的免疫原性,病毒-宿主关联研究,并阐明中和抗体在MARV治疗中的作用。
■本研究提供了对MARV在过去几十年中的当代地位和轨迹的全面见解。这使研究人员能够辨别新颖的合作前景,机构伙伴关系,新兴主题,并研究该领域的前沿。
UNASSIGNED: Marburg virus (MARV), a close relative of Ebola virus, could induce hemorrhagic fevers in humans with high mortality rate. In recent years, increasing attention has been paid to this highly lethal virus due to sporadic outbreaks observed in various African nations. This bibliometric analysis endeavors to elucidate the trends, dynamics, and focal points of knowledge that have delineated the landscape of research concerning MARV.
UNASSIGNED: Relevant literature on MARV from 1968 to 2023 was extracted from the Web of Science Core Collection database. Following this, the data underwent bibliometric analysis and visualization procedures utilizing online analysis platform, CiteSpace 6.2R6, and VOSviewer 1.6.20. Three different types of bibliometric indicators including quantitative indicator, qualitative indicators, and structural indicators were used to gauge a researcher\'s productivity, assess the quality of their work, and analyze publication relationships, respectively.
UNASSIGNED: MARV is mainly prevalent in Africa. And approximately 643 confirmed cases have been described in the literature to date, and mortality observed was 81.2 % in overall patients. A total of 1014 papers comprising 869 articles and 145 reviews were included. The annual publications showed an increasing growth pattern from 1968 to 2023 (R2 = 0.8838). The United States stands at the forefront of this discipline, having dedicated substantial financial and human resources to scientific inquiry. However, co-authorship analysis showed the international research collaboration needs to be further strengthened. Based on reference and keywords analysis, contemporary MARV research encompasses pivotal areas: primarily, prioritizing the creation of prophylactic vaccines to impede viral spread, and secondarily, exploring targeted antiviral strategies, including small-molecule antivirals or MARV-specific monoclonal antibodies. Additionally, a comprehensive grasp of viral transmission, transcription, and replication mechanisms remains a central focus in ongoing investigations. And future MARV studies are expected to focus on evaluating clinical trial safety and efficacy, developing inhibitors to contain viral spread, exploring vaccine immunogenicity, virus-host association studies, and elucidating the role of neutralizing antibodies in MARV treatment.
UNASSIGNED: The present study offered comprehensive insights into the contemporary status and trajectories of MARV over the past decades. This enables researchers to discern novel collaborative prospects, institutional partnerships, emerging topics, and research forefronts within this domain.