PDF(Pubmed)
Abstract：
UNASSIGNED: Macular edema results from many conditions, such as diabetic retinopathy, macular degeneration, inflammatory diseases, cataract operation, trauma, and tumors. Specifically, the capillary filtration rate should equal the speed of fluid removal from extracellular retinal tissue, such as the glial and retinal pigment epithelium cells layer (RPE). Once these forces are imbalanced, fluid accumulates in cystoid spaces within the inner layers of the retina.
UNASSIGNED: The main purpose of this case report is to show that macular edema caused by any inflammation, either bacteria, virus, or autoimmune origin, can be treated successfully, even if it is chronic.
UNASSIGNED: A 31-year-old man has been reported to our clinic with symptoms of blurry vision in the left eye, which occurred during the last year. Essential examinations included CDVA, IOP measurement, slit-lamp examination, indirect ophthalmoscopy, and OCT scan that showed significant macular edema (central foveal thickness of 353 microns). We initiated laboratory searches, such as blood, serology, and immunology testing for the next three months after his first visit, together with prescribed topical and periocular corticosteroid therapy. The test to VDRL (venereal disease research laboratory) for Syphilis and Toxocariasis came positive. We took the best decision and recommended further treatment with the intravitreal application of Dexamethasone Implant 0.7mg. One week after the intravitreal application of corticosteroids on the control exam, there were normal findings on the posterior segment with no macular edema (central foveal thickness of 269 microns).
UNASSIGNED: It is unexclusive that infection by Treponema pallidum (TP) causes isolated macular edema without any other symptoms on the anterior segment of the eye. It has indirect action on the macula, not just causing papilledema, retinal vasculitis, retinochoroiditis, and inflammatory disc edema, as expected. TP or the bacteria transmembrane protein (treponemal ligands) directly acting on vascular endothelial cells of the RPE cells, will be the key to the most certain mechanism of this condition. It is related to the possibility of the secretion of cytokines and the interactions between immune cells indirectly.
UNASSIGNED: The main purpose of this case report is to show that macular edema caused by any inflammation, either bacteria, virus, or autoimmune origin, can be treated successfully, even if it is chronic.
UNASSIGNED: A 31-year-old man has been reported to our clinic with symptoms of blurry vision in the left eye, which occurred during the last year. Essential examinations included CDVA, IOP measurement, slit-lamp examination, indirect ophthalmoscopy, and OCT scan that showed significant macular edema (central foveal thickness of 353 microns). We initiated laboratory searches, such as blood, serology, and immunology testing for the next three months after his first visit, together with prescribed topical and periocular corticosteroid therapy. The test to VDRL (venereal disease research laboratory) for Syphilis and Toxocariasis came positive. We took the best decision and recommended further treatment with the intravitreal application of Dexamethasone Implant 0.7mg. One week after the intravitreal application of corticosteroids on the control exam, there were normal findings on the posterior segment with no macular edema (central foveal thickness of 269 microns).
UNASSIGNED: It is unexclusive that infection by Treponema pallidum (TP) causes isolated macular edema without any other symptoms on the anterior segment of the eye. It has indirect action on the macula, not just causing papilledema, retinal vasculitis, retinochoroiditis, and inflammatory disc edema, as expected. TP or the bacteria transmembrane protein (treponemal ligands) directly acting on vascular endothelial cells of the RPE cells, will be the key to the most certain mechanism of this condition. It is related to the possibility of the secretion of cytokines and the interactions between immune cells indirectly.
摘要：
■黄斑水肿是由许多情况引起的，比如糖尿病视网膜病变，黄斑变性,炎症性疾病，白内障手术,创伤,和肿瘤。具体来说,毛细血管过滤速率应等于从细胞外视网膜组织去除液体的速度，如神经胶质和视网膜色素上皮细胞层(RPE)。一旦这些力量不平衡，液体积聚在视网膜内层的囊样空间中。
■本病例报告的主要目的是显示由任何炎症引起的黄斑水肿，无论是细菌，病毒,或自身免疫起源，可以成功治疗，即使它是慢性的。
据我们的诊所报告，一名31岁的男子出现左眼视力模糊的症状，这发生在去年。基本检查包括CDVA，眼压测量,裂隙灯检查,间接检眼镜,和OCT扫描显示显著黄斑水肿(中央凹厚度353微米)。我们启动了实验室搜索，比如血，血清学,在他第一次访问后的三个月进行免疫学测试，连同处方局部和眼周皮质类固醇治疗。VDRL（性病研究实验室）对梅毒和弓形虫病的测试呈阳性。我们做出了最好的决定，并建议玻璃体内应用地塞米松植入物0.7mg。在对照检查玻璃体内应用皮质类固醇一周后，后段有正常发现,无黄斑水肿(中央凹厚度269微米).
■梅毒螺旋体（TP）感染引起孤立的黄斑水肿，在眼前段没有任何其他症状，这是不唯一的。它对黄斑有间接作用，不仅仅是造成乳头水肿,视网膜血管炎,视网膜脉络膜炎,和炎性椎间盘水肿，如预期。TP或细菌跨膜蛋白（螺旋体配体）直接作用于RPE细胞的血管内皮细胞，将是这种情况最确定机制的关键。它与细胞因子分泌的可能性以及免疫细胞之间的相互作用间接相关。
■本病例报告的主要目的是显示由任何炎症引起的黄斑水肿，无论是细菌，病毒,或自身免疫起源，可以成功治疗，即使它是慢性的。
据我们的诊所报告，一名31岁的男子出现左眼视力模糊的症状，这发生在去年。基本检查包括CDVA，眼压测量,裂隙灯检查,间接检眼镜,和OCT扫描显示显著黄斑水肿(中央凹厚度353微米)。我们启动了实验室搜索，比如血，血清学,在他第一次访问后的三个月进行免疫学测试，连同处方局部和眼周皮质类固醇治疗。VDRL（性病研究实验室）对梅毒和弓形虫病的测试呈阳性。我们做出了最好的决定，并建议玻璃体内应用地塞米松植入物0.7mg。在对照检查玻璃体内应用皮质类固醇一周后，后段有正常发现,无黄斑水肿(中央凹厚度269微米).
■梅毒螺旋体（TP）感染引起孤立的黄斑水肿，在眼前段没有任何其他症状，这是不唯一的。它对黄斑有间接作用，不仅仅是造成乳头水肿,视网膜血管炎,视网膜脉络膜炎,和炎性椎间盘水肿，如预期。TP或细菌跨膜蛋白（螺旋体配体）直接作用于RPE细胞的血管内皮细胞，将是这种情况最确定机制的关键。它与细胞因子分泌的可能性以及免疫细胞之间的相互作用间接相关。
