PDF(Pubmed)
Abstract：
A 12-year-old castrated male poodle presented with vomiting and diarrhea. Ultrasonography and computed tomography revealed a protruding mass at the caudal pole of the left kidney. Grossly, the poorly circumscribed abnormal mass was 1.6 × 1.8 × 1.9 cm in size and had multifocal dark-red foci. Microscopically, it was composed of densely or loosely packed variable-sized short spindle or ovoid cells. These neoplastic cells showed high pleomorphism, mitotic figures, and invasive tendency to the adjacent tissue. Immunohistochemically, the neoplastic spindle cells expressed vimentin, S100, neuron-specific enolase, nerve growth factor receptor, and laminin. Therefore, the mass was diagnosed as a malignant peripheral nerve sheath tumor (MPNST). To our knowledge, this is the first report of primary renal MPNST in a dog.
摘要：
一只12岁阉割的雄性贵宾犬出现呕吐和腹泻。超声检查和计算机断层扫描显示左肾尾极有突出的肿块。严重的,界限不清的异常肿块大小为1.6×1.8×1.9cm，有多灶性暗红色病灶。微观上,它由密集或松散堆积的可变大小的短纺锤形或卵形细胞组成。这些肿瘤细胞表现出高度的多态性，有丝分裂图,和对邻近组织的侵入性倾向。免疫组织化学，肿瘤梭形细胞表达波形蛋白，S100,神经元特异性烯醇化酶,神经生长因子受体，还有层粘连蛋白.因此,肿块被诊断为恶性周围神经鞘瘤（MPNST）。据我们所知,这是狗原发性肾MPNST的首次报道。
