{Reference Type}: Journal Article
{Title}: Malignant peripheral nerve sheath tumor in the kidney of a dog.
{Author}: Nam DY;Jang SH;Yim SJ;Kim JH;Jung JY;
{Journal}: J Vet Med Sci
{Volume}: 86
{Issue}: 3
{Year}: 2024 Mar 16
{Factor}: 1.105
{DOI}: 10.1292/jvms.23-0385
{Abstract}: A 12-year-old castrated male poodle presented with vomiting and diarrhea. Ultrasonography and computed tomography revealed a protruding mass at the caudal pole of the left kidney. Grossly, the poorly circumscribed abnormal mass was 1.6 × 1.8 × 1.9 cm in size and had multifocal dark-red foci. Microscopically, it was composed of densely or loosely packed variable-sized short spindle or ovoid cells. These neoplastic cells showed high pleomorphism, mitotic figures, and invasive tendency to the adjacent tissue. Immunohistochemically, the neoplastic spindle cells expressed vimentin, S100, neuron-specific enolase, nerve growth factor receptor, and laminin. Therefore, the mass was diagnosed as a malignant peripheral nerve sheath tumor (MPNST). To our knowledge, this is the first report of primary renal MPNST in a dog.