%0 Journal Article
%T Malignant peripheral nerve sheath tumor in the kidney of a dog.
%A Nam DY
%A Jang SH
%A Yim SJ
%A Kim JH
%A Jung JY
%J J Vet Med Sci
%V 86
%N 3
%D 2024 Mar 16
%M 38296525
%F 1.105
%R 10.1292/jvms.23-0385
%X A 12-year-old castrated male poodle presented with vomiting and diarrhea. Ultrasonography and computed tomography revealed a protruding mass at the caudal pole of the left kidney. Grossly, the poorly circumscribed abnormal mass was 1.6 × 1.8 × 1.9 cm in size and had multifocal dark-red foci. Microscopically, it was composed of densely or loosely packed variable-sized short spindle or ovoid cells. These neoplastic cells showed high pleomorphism, mitotic figures, and invasive tendency to the adjacent tissue. Immunohistochemically, the neoplastic spindle cells expressed vimentin, S100, neuron-specific enolase, nerve growth factor receptor, and laminin. Therefore, the mass was diagnosed as a malignant peripheral nerve sheath tumor (MPNST). To our knowledge, this is the first report of primary renal MPNST in a dog.