Abstract：
BACKGROUND: Recurrent Cushing\'s disease (recurrent CD) is an uncommon and intricate clinical form of Cushing\'s syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain.
METHODS: A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.
CONCLUSIONS: This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.
METHODS: A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.
CONCLUSIONS: This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.
摘要：
背景：复发性库欣病（复发性CD）是库欣综合征的一种罕见且复杂的临床形式。然而,分泌ACTH的PitNETs的病理类型与复发性CD的临床体征之间的联系仍不确定。
方法：一位64岁的女性，以前被诊断患有肾癌，因最近体重增加而入院。先前的内分泌测试表明，过去六年来，高皮质醇血症和垂体肿瘤复发。她做了两次经蝶垂体切除术,和肿瘤的组织病理学分析显示它是一个密集的颗粒状的促肾上腺细胞肿瘤（DGCT），TPIT谱系PitNET的一个亚型，伴有肿瘤中风。
结论：该病例强调了复发性CD与TPIT谱系DGCT-PitNETs病理亚型之间的联系。
方法：一位64岁的女性，以前被诊断患有肾癌，因最近体重增加而入院。先前的内分泌测试表明，过去六年来，高皮质醇血症和垂体肿瘤复发。她做了两次经蝶垂体切除术,和肿瘤的组织病理学分析显示它是一个密集的颗粒状的促肾上腺细胞肿瘤（DGCT），TPIT谱系PitNET的一个亚型，伴有肿瘤中风。
结论：该病例强调了复发性CD与TPIT谱系DGCT-PitNETs病理亚型之间的联系。
