%0 Case Reports
%T Recurrent Cushing's Disease Caused by a TPIT-Lineage Densely Granulated Corticotroph Pituitary Neuroendocrine Tumor: A Case Report.
%A Wu W
%A Fu X
%A Guo W
%A Chen H
%J Neuro Endocrinol Lett
%V 45
%N 1
%D 2024 Jan 31
%M 38295430
%F 0.638
%X <B>BACKGROUND: </B>Recurrent Cushing's disease (recurrent CD) is an uncommon and intricate clinical form of Cushing's syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain.<BR><B>METHODS: </B>A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.<BR><B>CONCLUSIONS: </B>This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.