{Reference Type}: Case Reports
{Title}: Recurrent Cushing's Disease Caused by a TPIT-Lineage Densely Granulated Corticotroph Pituitary Neuroendocrine Tumor: A Case Report.
{Author}: Wu W;Fu X;Guo W;Chen H;
{Journal}: Neuro Endocrinol Lett
{Volume}: 45
{Issue}: 1
{Year}: 2024 Jan 31
{Factor}: 0.638
{Abstract}: <B>BACKGROUND: </B>Recurrent Cushing's disease (recurrent CD) is an uncommon and intricate clinical form of Cushing's syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain.<BR><B>METHODS: </B>A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.<BR><B>CONCLUSIONS: </B>This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.