PDF(Pubmed)
Abstract：
We investigated whether retrograde amnesia for the stress-induced impairment of extinction retrieval shares similar characteristics with original acquisition memories. The first experiment demonstrated that cycloheximide administered shortly after a single restraint stress session alleviated the impairment of extinction retrieval but not when administered following a longer delay (i.e., the amnesia for stress is time-dependent). A second experiment showed that the retrograde amnesia for stress could be alleviated by a second brief exposure to the stressor. These results demonstrating that amnesia for stress shares characteristics similar to original memories are explained using a retrieval-based memory integration model of retrograde amnesia.
摘要：
我们调查了由压力引起的灭绝恢复障碍的逆行健忘症是否与原始采集记忆具有相似的特征。第一个实验表明，在一次束缚应激反应后不久施用环己酰亚胺可以减轻灭绝恢复的损害，但在较长时间的延迟后施用时却没有（即，压力的健忘症是时间依赖性的)。第二个实验表明，对压力的逆行性健忘症可以通过第二次短暂暴露于压力源来缓解。这些结果表明，使用基于检索的逆行性健忘症记忆整合模型来解释压力健忘症具有与原始记忆相似的特征。
