%0 Journal Article
%T Retrograde amnesia for the stress-induced impairment of extinction: time-dependent and not so forgotten.
%A Briggs JF
%A McMullen KM
%J Learn Mem
%V 31
%N 1
%D 2024 Jan-Feb
%M 38286522
%F 2.699
%R 10.1101/lm.053895.123
%X We investigated whether retrograde amnesia for the stress-induced impairment of extinction retrieval shares similar characteristics with original acquisition memories. The first experiment demonstrated that cycloheximide administered shortly after a single restraint stress session alleviated the impairment of extinction retrieval but not when administered following a longer delay (i.e., the amnesia for stress is time-dependent). A second experiment showed that the retrograde amnesia for stress could be alleviated by a second brief exposure to the stressor. These results demonstrating that amnesia for stress shares characteristics similar to original memories are explained using a retrieval-based memory integration model of retrograde amnesia.