PDF(Pubmed)
Abstract：
The current studies explore the effect of omega-3 polyunsaturated fatty acids (PUFAs) on appetite.
To examine the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on appetite using a systematic review and meta-analysis of controlled clinical trials (CTs).
Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to January 2022. A random-effects model was used to compare the overall standardized mean difference in appetite scores between n-3 PUFAs supplemented and control individuals.
Fifteen eligible CTs with 1504 participants (872 for n-3 PUFA supplementation and 632 for placebo groups) were included in our systematic review. The meta-analysis showed no significant difference in overall appetite score between n-3 PUFAs supplemented and control groups (standardized mean difference [SMD] = 0.458, 95% confidence interval [CI] - 0.327, 1.242, P value = 0.25). However, the n-3 PUFA supplementation significantly increased the desire to eat (SMD = 1.07, 95% CI 0.116, 2.029, P = 0.02) compared to control.
Although we found no effect of omega-3 supplementation on overall appetite score, it modestly increases the desire to eat. Further CTs evaluating the effect of PUFAs on appetite are still needed to confirm these findings.
To examine the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on appetite using a systematic review and meta-analysis of controlled clinical trials (CTs).
Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to January 2022. A random-effects model was used to compare the overall standardized mean difference in appetite scores between n-3 PUFAs supplemented and control individuals.
Fifteen eligible CTs with 1504 participants (872 for n-3 PUFA supplementation and 632 for placebo groups) were included in our systematic review. The meta-analysis showed no significant difference in overall appetite score between n-3 PUFAs supplemented and control groups (standardized mean difference [SMD] = 0.458, 95% confidence interval [CI] - 0.327, 1.242, P value = 0.25). However, the n-3 PUFA supplementation significantly increased the desire to eat (SMD = 1.07, 95% CI 0.116, 2.029, P = 0.02) compared to control.
Although we found no effect of omega-3 supplementation on overall appetite score, it modestly increases the desire to eat. Further CTs evaluating the effect of PUFAs on appetite are still needed to confirm these findings.
摘要：
背景：目前的研究探讨了omega-3多不饱和脂肪酸（PUFA）对食欲的影响。
目的：使用对照临床试验（CT）的系统评价和荟萃分析，研究ω-3多不饱和脂肪酸（n-3PUFA）对食欲的影响。
方法：在线数据库，包括PubMed、Scopus,ISIWebofScience,和谷歌学者被搜索到2022年1月。使用随机效应模型来比较补充n-3PUFA和对照个体之间的食欲评分的总体标准化平均差异。
结果：我们的系统评价包括15个符合条件的CTs和1504个参与者（补充n-3PUFA872个和安慰剂组632个）。荟萃分析显示，补充n-3PUFA的总食欲评分与对照组之间没有显着差异（标准化平均差[SMD]=0.458，95％置信区间[CI]-0.327，1.242，P值=0.25）。然而,与对照组相比，补充n-3PUFA显着增加了进食欲望（SMD=1.07，95％CI0.116，2.029，P=0.02）。
结论：尽管我们发现补充omega-3对总体食欲评分没有影响，它适度地增加了吃的欲望。仍需要进一步的CT评估PUFA对食欲的影响以证实这些发现。
目的：使用对照临床试验（CT）的系统评价和荟萃分析，研究ω-3多不饱和脂肪酸（n-3PUFA）对食欲的影响。
方法：在线数据库，包括PubMed、Scopus,ISIWebofScience,和谷歌学者被搜索到2022年1月。使用随机效应模型来比较补充n-3PUFA和对照个体之间的食欲评分的总体标准化平均差异。
结果：我们的系统评价包括15个符合条件的CTs和1504个参与者（补充n-3PUFA872个和安慰剂组632个）。荟萃分析显示，补充n-3PUFA的总食欲评分与对照组之间没有显着差异（标准化平均差[SMD]=0.458，95％置信区间[CI]-0.327，1.242，P值=0.25）。然而,与对照组相比，补充n-3PUFA显着增加了进食欲望（SMD=1.07，95％CI0.116，2.029，P=0.02）。
结论：尽管我们发现补充omega-3对总体食欲评分没有影响，它适度地增加了吃的欲望。仍需要进一步的CT评估PUFA对食欲的影响以证实这些发现。
