Abstract：
Sumalarins D-G (1-4), four previously undescribed curvularin derivatives, along with two known related metabolites, curvularin (5) and dehydrocurvularin (6), were isolated and identified from the mangrove-derived fungus Penicillium sumatrense MA-325. Among them, sumalarin D (1) represents a unique example of curvularin derivative featuring a 5-methylfuran-2-yl-methyl group. Their structures were elucidated based on analysis of NMR and MS data as well as comparison of ECD spectra and quantum chemical calculations of NMR, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, 5, and 6 are active against aquatic pathogenic bacteria Vibrio alginolyticus and V. harveyi with MIC values ranging from 4 to 64 μg/mL, while compound 6 is cytotoxic against tumor cell lines 5673, HCT 116, 786-O, and Hela with IC50 values of 3.5, 10.6, 10.9, and 14.9 μM, respectively.
摘要：
SumalarinsD-G（1-4），四种先前未描述的卷曲素衍生物，以及两种已知的相关代谢物，curvularin（5）和脱氢curvularin（6），从红树林衍生的真菌summatrense青霉MA-325中分离并鉴定。其中,sumalarinD（1）代表具有5-甲基呋喃-2-基甲基基团的curvularin衍生物的独特实例。根据对NMR和MS数据的分析以及对ECD光谱和NMR的量子化学计算的比较，阐明了它们的结构。和化合物1通过X射线晶体学分析证实。化合物1、2、5和6对水生致病菌溶藻弧菌和哈氏弧菌具有活性，MIC值为4至64μg/mL，而化合物6对肿瘤细胞系5673、HCT116、786-O具有细胞毒性，和Hela，IC50值为3.5、10.6、10.9和14.9μM，分别。
