%0 Journal Article
%T Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325.
%A Wang YR
%A Dong YL
%A Li XM
%A Shi XS
%A Li HL
%A Meng LH
%A Xu R
%A Wang BG
%J Phytochemistry
%V 220
%N 0
%D 2024 Apr 24
%M 38278465
%F 4.004
%R 10.1016/j.phytochem.2024.114000
%X Sumalarins D-G (1-4), four previously undescribed curvularin derivatives, along with two known related metabolites, curvularin (5) and dehydrocurvularin (6), were isolated and identified from the mangrove-derived fungus Penicillium sumatrense MA-325. Among them, sumalarin D (1) represents a unique example of curvularin derivative featuring a 5-methylfuran-2-yl-methyl group. Their structures were elucidated based on analysis of NMR and MS data as well as comparison of ECD spectra and quantum chemical calculations of NMR, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, 5, and 6 are active against aquatic pathogenic bacteria Vibrio alginolyticus and V. harveyi with MIC values ranging from 4 to 64 μg/mL, while compound 6 is cytotoxic against tumor cell lines 5673, HCT 116, 786-O, and Hela with IC50 values of 3.5, 10.6, 10.9, and 14.9 μM, respectively.