{Reference Type}: Journal Article
{Title}: Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325.
{Author}: Wang YR;Dong YL;Li XM;Shi XS;Li HL;Meng LH;Xu R;Wang BG;
{Journal}: Phytochemistry
{Volume}: 220
{Issue}: 0
{Year}: 2024 Apr 24
{Factor}: 4.004
{DOI}: 10.1016/j.phytochem.2024.114000
{Abstract}: Sumalarins D-G (1-4), four previously undescribed curvularin derivatives, along with two known related metabolites, curvularin (5) and dehydrocurvularin (6), were isolated and identified from the mangrove-derived fungus Penicillium sumatrense MA-325. Among them, sumalarin D (1) represents a unique example of curvularin derivative featuring a 5-methylfuran-2-yl-methyl group. Their structures were elucidated based on analysis of NMR and MS data as well as comparison of ECD spectra and quantum chemical calculations of NMR, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, 5, and 6 are active against aquatic pathogenic bacteria Vibrio alginolyticus and V. harveyi with MIC values ranging from 4 to 64 μg/mL, while compound 6 is cytotoxic against tumor cell lines 5673, HCT 116, 786-O, and Hela with IC50 values of 3.5, 10.6, 10.9, and 14.9 μM, respectively.