PDF(Pubmed)
Abstract：
OBJECTIVE: This systematic review aims to evaluate the efficacy of combining the amniotic membrane (AM) with the coronally advanced flap (CAF) in the treatment of Miller class I and II gingival recession (GR).
METHODS: The protocol of this updated PRISMA-compliant systematic review was registered in PROSPERO (CRD42023431501). The following treatment outcomes were recorded; recession depth (RD), recession width (RW), width of keratinized gingiva (WKG), and clinical attachment level (CAL). We searched the following databases: MEDLINE, Cochrane Library, Google Scholar, EMBASE, Web of Science, and Science Direct.
RESULTS: Two independent reviewers screened the selected articles. Twenty-two eligible articles were extracted, with 689 sites of GR in 481 patients. No statistically significant difference was found in RD, RW, WKG, and CAL between (AM&CAF) in comparison to control groups. However, the subgroup analysis showed statistically significant differences in RD between the (AM & CAF) group v/s (CAF) alone (P = 0.004). Moreover, the subgroup analysis of the WKG showed statistically significant differences between (AM & CAF) v/s (CAF&CM) (p = 0.04). Additionally, a statistically significant difference was found in the subgroup analysis of CAL between both (AM & CAF) group v/s (CAF) alone (p = 0.0009).
CONCLUSIONS: With the limitations of this meta-analysis due to short follow-up periods (6 months), the AM can be considered a viable treatment option for GR defects with satisfactory treatment outcomes comparable to other previously investigated treatment modalities.
CONCLUSIONS: While AM showed various beneficial properties as an ideal membrane for the coverage of GR, future studies are required to completely understand the potential application of AM in the treatment of GR.
METHODS: The protocol of this updated PRISMA-compliant systematic review was registered in PROSPERO (CRD42023431501). The following treatment outcomes were recorded; recession depth (RD), recession width (RW), width of keratinized gingiva (WKG), and clinical attachment level (CAL). We searched the following databases: MEDLINE, Cochrane Library, Google Scholar, EMBASE, Web of Science, and Science Direct.
RESULTS: Two independent reviewers screened the selected articles. Twenty-two eligible articles were extracted, with 689 sites of GR in 481 patients. No statistically significant difference was found in RD, RW, WKG, and CAL between (AM&CAF) in comparison to control groups. However, the subgroup analysis showed statistically significant differences in RD between the (AM & CAF) group v/s (CAF) alone (P = 0.004). Moreover, the subgroup analysis of the WKG showed statistically significant differences between (AM & CAF) v/s (CAF&CM) (p = 0.04). Additionally, a statistically significant difference was found in the subgroup analysis of CAL between both (AM & CAF) group v/s (CAF) alone (p = 0.0009).
CONCLUSIONS: With the limitations of this meta-analysis due to short follow-up periods (6 months), the AM can be considered a viable treatment option for GR defects with satisfactory treatment outcomes comparable to other previously investigated treatment modalities.
CONCLUSIONS: While AM showed various beneficial properties as an ideal membrane for the coverage of GR, future studies are required to completely understand the potential application of AM in the treatment of GR.
摘要：
目的：本系统综述旨在评估羊膜（AM）与冠状晚期皮瓣（CAF）联合治疗MillerI级和II级牙龈萎缩（GR）的疗效。
方法：此更新的符合PRISMA的系统评价方案在PROSPERO（CRD42023431501）中注册。记录以下治疗结果；衰退深度（RD），衰退宽度(RW)，角化牙龈宽度（WKG），和临床依恋水平（CAL）。我们搜索了以下数据库:MEDLINE,科克伦图书馆,谷歌学者，EMBASE,WebofScience,科学直接。
结果：两名独立评审员筛选了选定的文章。提取了22篇符合条件的文章，481例患者有689个GR位点。RD差异无统计学意义，RW,WKG,与对照组相比，（AM和CAF）之间的CAL。然而,亚组分析显示,仅(AM&CAF)组v/s(CAF)间的RD差异有统计学意义(P=0.004).此外，WKG的亚组分析显示(AM&CAF)v/s(CAF&CM)之间存在统计学差异(p=0.04).此外,在CAL的亚组分析中,发现两个(AM和CAF)组之间的单独v/s(CAF)差异有统计学意义(p=0.0009).
结论：由于随访时间短（6个月），本荟萃分析的局限性，AM可以被认为是治疗GR缺陷的可行选择,其治疗结果与之前研究的其他治疗方式相当。
结论：虽然AM作为覆盖GR的理想膜表现出各种有益特性，未来的研究需要全面了解AM在治疗GR中的潜在应用。
方法：此更新的符合PRISMA的系统评价方案在PROSPERO（CRD42023431501）中注册。记录以下治疗结果；衰退深度（RD），衰退宽度(RW)，角化牙龈宽度（WKG），和临床依恋水平（CAL）。我们搜索了以下数据库:MEDLINE,科克伦图书馆,谷歌学者，EMBASE,WebofScience,科学直接。
结果：两名独立评审员筛选了选定的文章。提取了22篇符合条件的文章，481例患者有689个GR位点。RD差异无统计学意义，RW,WKG,与对照组相比，（AM和CAF）之间的CAL。然而,亚组分析显示,仅(AM&CAF)组v/s(CAF)间的RD差异有统计学意义(P=0.004).此外，WKG的亚组分析显示(AM&CAF)v/s(CAF&CM)之间存在统计学差异(p=0.04).此外,在CAL的亚组分析中,发现两个(AM和CAF)组之间的单独v/s(CAF)差异有统计学意义(p=0.0009).
结论：由于随访时间短（6个月），本荟萃分析的局限性，AM可以被认为是治疗GR缺陷的可行选择,其治疗结果与之前研究的其他治疗方式相当。
结论：虽然AM作为覆盖GR的理想膜表现出各种有益特性，未来的研究需要全面了解AM在治疗GR中的潜在应用。
