背景:对受损皮肤的完美修复一直是科学家的永恒目标;但是,皮肤的修复和重建仍然是损伤和烧伤医学的主要问题和挑战。人羊膜(hAM),具有良好的机械性能和抗炎作用,抗氧化和抗菌的好处,含有促进伤口愈合的生长因子,在过去的几十年里,从简单的皮肤床单发展到高科技敷料,比如被制成纳米复合材料,水凝胶,粉末,和静电纺丝支架。本文旨在探讨历史发展,应用程序,趋势,以及hAM在创面愈合中的研究热点。
方法:我们检查了1975年1月1日至2023年7月12日在WebofScienceCoreCollection(WoSCC)中索引的2660种出版物。利用文献计量学方法,我们雇佣了VOSwiewer,CiteSpace,和R-bibliometrix来表征一般信息,确定发展趋势,突出研究热点。随后,我们确定了一系列高质量的英文文章,重点关注人羊膜上皮干细胞(hAESCs)的作用,人羊膜间充质干细胞(hAMSCs),羊膜(AM)支架在再生医学和组织工程中的应用。
结果:文献计量分析确定Udice-French研究型大学是最有生产力的隶属关系,TsengS.C.G.是最多产的作者。关键词分析,历史直接报价网,主题分析帮助我们回顾了该领域的历史和主要主题。我们的考试包括知识结构,全球地位,趋势,以及hAM在创面愈合中应用的研究热点。我们的发现表明,当代研究强调了源自hAM的产品的制备和应用。值得注意的是,hAM和从其分离的细胞-hADSCs和hAESCs是再生医学和组织工程中突出和有希望的研究领域。
结论:这项研究提供了对知识框架的全面理解,全球动态,新兴模式,以及在伤口愈合中应用hAM领域的主要研究重点。该领域正在迅速发展,我们的发现为研究人员提供了有价值的见解。未来的研究结果有望应用于临床实践,加强疾病预防方法,诊断,和治疗。
BACKGROUND: The perfect repair of damaged skin has always been a constant goal for scientists; however, the repair and reconstruction of skin is still a major problem and challenge in injury and burns medicine. Human amniotic membrane (hAM), with its good mechanical properties and anti-inflammatory, antioxidant and antimicrobial benefits, containing growth factors that promote wound healing, has evolved over the last few decades from simple skin sheets to high-tech dressings, such as being made into nanocomposites, hydrogels, powders, and electrostatically spun scaffolds. This paper aims to explore the historical development, applications, trends, and research hotspots of hAM in wound healing.
METHODS: We examined 2660 publications indexed in the Web of Science Core Collection (WoSCC) from January 1, 1975 to July 12, 2023. Utilizing bibliometric methods, we employed VOSviewer, CiteSpace, and R-bibliometrix to characterize general information, identify development trends, and highlight research hotspots. Subsequently, we identified a collection of high-quality English articles focusing on the roles of human amniotic epithelial stem cells (hAESCs), human amniotic mesenchymal stem cells (hAMSCs), and amniotic membrane (AM) scaffolds in regenerative medicine and tissue engineering.
RESULTS: Bibliometric analysis identified Udice-French Research Universities as the most productive affiliation and Tseng S.C.G. as the most prolific author. Keyword analysis, historical direct quotations network, and thematic analysis helped us review the historical and major themes in this field. Our examination included the knowledge structure, global status, trends, and research hotspots regarding the application of hAM in wound healing. Our findings indicate that contemporary research emphasizes the preparation and application of products derived from hAM. Notably, both hAM and the cells isolated from it - hADSCs and hAESCs are prominent and promising areas of research in regenerative medicine and tissue engineering.
CONCLUSIONS: This research delivers a comprehensive understanding of the knowledge frameworks, global dynamics, emerging patterns, and primary research foci in the realm of hAM applications for wound healing. The field is rapidly evolving, and our findings offer valuable insights for researchers. Future research outcomes are anticipated to be applied in clinical practice, enhancing methods for disease prevention, diagnosis, and treatment.