PDF(Pubmed)
Abstract：
This meta-analysis aimed to evaluate the effects of flaxseed supplementation on weight loss, lipid profiles, high-sensitivity C-reactive protein (hs-CRP), and glucose levels in patients with coronary artery disease (CAD). A systematic search was performed using various online databases, including Scopus, PubMed, Web of Science, EMBASE, and Cochrane Library, to identify relevant randomized controlled trials (RCTs) until June 2023. To evaluate heterogeneity among the selected studies, the Q-test and I2 statistics were employed. Data were combined using either a fixed- or random-effects model and presented as a weighted mean difference (WMD) with a 95% confidence interval (CI). Of the 428 citations, six RCTs were included. The pooled results did not show significant changes in the WMD of lipid factors (high-density lipoprotein cholesterol, triglycerides (TG), low-density lipoprotein cholesterol, and total cholesterol) following flaxseed intake. However, after performing a sensitivity analysis to determine the source of heterogeneity, flaxseed supplementation resulted in a significant decrease in TG levels (WMD = -18.39 mg/dL; 95% CI: -35.02, -1.75). Moreover, no significant differences were observed in either weight or BMI following flaxseed intake. However, the circulating levels of fasting blood glucose (WMD = -8.35 mg/dL; 95% CI: -15.01, -1.69, p = .01) and hs-CRP (WMD = -1.35 mg/L; 95% CI: -1.93, -0.77, p < .01) significantly decreased after the intervention. Flaxseed supplementation was associated with lowering FBS, hs-CRP, and TG levels but did not affect weight loss parameters and other lipid markers in CAD.
摘要：
这项荟萃分析旨在评估亚麻籽补充剂对减肥的影响，脂质分布，高敏C反应蛋白(hs-CRP),冠心病（CAD）患者的血糖水平。使用各种在线数据库进行了系统的搜索，包括Scopus,PubMed,WebofScience,EMBASE,和Cochrane图书馆,确定相关的随机对照试验（RCT），直至2023年6月。为了评估选定研究之间的异质性，采用Q检验和I2统计量。使用固定或随机效应模型合并数据，并以加权平均差（WMD）表示，置信区间为95％（CI）。在428次引用中，纳入了6个随机对照试验。汇总结果未显示脂质因子（高密度脂蛋白胆固醇，甘油三酯（TG），低密度脂蛋白胆固醇，和总胆固醇）摄入亚麻籽后。然而,在进行敏感性分析以确定异质性的来源后，补充亚麻籽导致TG水平显着降低（WMD=-18.39mg/dL；95％CI：-35.02，-1.75）。此外，摄入亚麻籽后体重或BMI均无显著差异.然而,干预后空腹血糖循环水平(WMD=-8.35mg/dL;95%CI:-15.01,-1.69,p=0.01)和hs-CRP(WMD=-1.35mg/L;95%CI:-1.93,-0.77,p<0.01)显著下降。补充亚麻籽与降低FBS有关，hs-CRP,和TG水平，但不影响CAD的体重减轻参数和其他脂质标志物。
